Biology:IS061 RNA
From HandWiki
| IS061 RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of IS061 | |
| Identifiers | |
| Symbol | IS061 |
| Rfam | RF00115 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | 0001263 |
| PDB structures | PDBe |
The ISO61 (IsrA) RNA is a bacterial non-coding RNA that is found between the abgR and ydaL genes in Escherichia coli and Shigella flexneri. It was discovered using a computational screen of the E. coli genome.[1] Subsequent characterisation of ISO61 region has revealed that the reverse strand is actually a CsrA binding ncRNA called McaS and that it has a role in biofilm formation control.[2] Furthermore, it has been shown that McaS(IsrA) exists as ribonucleoprotein particles (sRNPs), which involve a defined set of proteins including Hfq, S1, CsrA, ProQ and PNPase. [3]
See also
References
- ↑ "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Bio Systems 65 (2–3): 157–177. 2002. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726.
- ↑ "Dual function of the McaS small RNA in controlling biofilm formation". Genes & Development 27 (10): 1132–1145. May 2013. doi:10.1101/gad.214734.113. PMID 23666921.
- ↑ "Ribonucleoprotein particles of bacterial small non-coding RNA IsrA (IS61 or McaS) and its interaction with RNA polymerase core may link transcription to mRNA fate". Nucleic Acids Research 44 (6): 2577–2592. April 2016. doi:10.1093/nar/gkv1302. PMID 26609136.
External links
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