Biology:ITPK1
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Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.[1][2][3]
It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.[4][5]
References
- ↑ "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem 271 (20): 11904–10. Aug 1996. doi:10.1074/jbc.271.20.11904. PMID 8662638.
- ↑ "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J 351 (3): 551–5. Jan 2001. doi:10.1042/0264-6021:3510551. PMID 11042108.
- ↑ "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3705.
- ↑ "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal 1 (4): pe5. 2008. doi:10.1126/stke.14pe5. PMID 18272466.
- ↑ "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. September 2007. doi:10.1074/jbc.M703121200. PMID 17616525.
Further reading
- "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.". J. Biol. Chem. 276 (44): 40998–1004. 2001. doi:10.1074/jbc.M106605200. PMID 11533064.
- "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.". Curr. Biol. 12 (6): 477–82. 2002. doi:10.1016/S0960-9822(02)00713-3. PMID 11909533.
- "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.". J. Biol. Chem. 277 (48): 45759–64. 2003. doi:10.1074/jbc.M208709200. PMID 12324474.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.". J. Biol. Chem. 278 (44): 43645–53. 2003. doi:10.1074/jbc.M300674200. PMID 12925536.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.". Biochem. J. 389 (Pt 2): 389–95. 2005. doi:10.1042/BJ20050297. PMID 15762844.
- "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.". Mol. Cell 18 (2): 201–12. 2005. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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