Biology:Jumping translocation breakpoint
 Generic protein structure example |
| Jumping translocation breakpoint protein (JTB) | |||||||||
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| Identifiers | |||||||||
| Symbol | JTB | ||||||||
| Pfam | PF05439 | ||||||||
| InterPro | IPR008657 | ||||||||
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The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.[1][2] It is an orphan receptor with unknown function.[3]
The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).[1] JTB has also been implicated in prostatic carcinomas.[4]
References
- ↑ 1.0 1.1 "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene 18 (12): 2085–90. Jun 1999. doi:10.1038/sj.onc.1202510. PMID 10321732.
- ↑ "Entrez Gene: JTB jumping translocation breakpoint". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10899.
- ↑ Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049.
- ↑ "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. May 2000. doi:10.3892/ijo.16.5.1055. PMID 10762645.
Further reading
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wong N; Chan A; Lee SW et al. (2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". J. Hepatol. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Zhang QH; Ye M; Wu XY et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152.
- Platica O; Chen S; Ivan E et al. (2000). "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. doi:10.3892/ijo.16.5.1055. PMID 10762645.
- Yu W; Andersson B; Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMID 9110174.
- Andersson B; Wentland MA; Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB
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