Biology:KIAA0101
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PCNA-associated factor is a protein that in humans is encoded by the KIAA0101 gene.[1][2][3]
Interactions
KIAA0101 has been shown to interact with PCNA.[1]
Model organisms
Model organisms have been used in the study of KIAA0101 function. A conditional knockout mouse line called 2810417H13Riktm1a (EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10] - in-depth bone and cartilage phenotyping[11]
| Characteristic | Phenotype |
|---|---|
| All data available at.[5][10][11] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Abnormal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Trichuris Challenge | Normal |
References
- ↑ 1.0 1.1 "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene 20 (4): 484–9. Jan 2001. doi:10.1038/sj.onc.1204113. PMID 11313979.
- ↑ "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research 312 (1): 73–85. Jan 2006. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.
- ↑ "Entrez Gene: KIAA0101 KIAA0101". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9768.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 5.0 5.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=2810417H13Rik#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. Jul 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 10.0 10.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=2810417H13Rik&field_gene_construct_tid=All.
- ↑ 11.0 11.1 "OBCD Consortium". http://www.boneandcartilage.com/.
Further reading
- "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters 259 (2): 192–7. Feb 2008. doi:10.1016/j.canlet.2007.10.029. PMID 18068894.
- "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma". BMC Cancer 6: 109. 2006. doi:10.1186/1471-2407-6-109. PMID 16646990.
- "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma". Cancer 103 (9): 1785–90. May 2005. doi:10.1002/cncr.20988. PMID 15789362.
- "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene 23 (46): 7734–45. Oct 2004. doi:10.1038/sj.onc.1207921. PMID 15334068.
- "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (1): 37–43. 1995. doi:10.1093/dnares/2.1.37. PMID 7788527.
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