Biology:KMO (gene)
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Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.[1][2]
Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM][2] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections.[3] The KMO gene is upregulated in the lung parenchyma of smokers. [4]
References
- ↑ "Cloning and functional expression of human kynurenine 3-monooxygenase". FEBS Lett 410 (2–3): 407–12. Sep 1997. doi:10.1016/S0014-5793(97)00627-3. PMID 9237672.
- ↑ 2.0 2.1 "Entrez Gene: KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8564.
- ↑ "Inflammation-associated Depression: From Serotonin to Kyneurenine", Psychoneuroendocrinology 36 (3): 426–36, 2011, doi:10.1016/j.psyneuen.2010.09.012, PMID 21041030
- ↑ "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports 9 (1): 13039. September 2019. doi:10.1038/s41598-019-49648-2. PMID 31506599. Bibcode: 2019NatSR...913039P.
Further reading
- "Endogenous kynurenines as targets for drug discovery and development.". Nature Reviews. Drug Discovery 1 (8): 609–20. 2002. doi:10.1038/nrd870. PMID 12402501.
- "Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.". Genes, Brain and Behavior 5 (4): 364–8. 2006. doi:10.1111/j.1601-183X.2006.00231.x. PMID 16716206.
- "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy.". Placenta 26 (6): 498–504. 2005. doi:10.1016/j.placenta.2004.08.009. PMID 15950064.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43.". Genomics 72 (2): 203–8. 2001. doi:10.1006/geno.2001.6469. PMID 11401433.
- "Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.". Eur. J. Biochem. 267 (4): 1092–9. 2000. doi:10.1046/j.1432-1327.2000.01104.x. PMID 10672018.
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