Biology:KSR1

Short description: Protein-coding gene in the species Homo sapiens

For the KSR1 supercomputer, see Kendall Square Research.

Generic protein structure example

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.

Further reading

• "KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1". Exp. Cell Res. 317 (4): 452–63. 2011. doi:10.1016/j.yexcr.2010.11.018. PMID 21144847. 
• "Inflammatory bowel disease reveals the kinase activity of KSR1". J. Clin. Invest. 114 (9): 1233–7. 2004. doi:10.1172/JCI23441. PMID 15520853. 
• "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras". J. Biol. Chem. 275 (23): 17276–80. 2000. doi:10.1074/jbc.C900989199. PMID 10764733. 
• "MAP kinase module: the Ksr connection". Curr. Biol. 12 (9): R325–7. 2002. doi:10.1016/S0960-9822(02)00831-X. PMID 12007434. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature 427 (6971): 256–60. 2004. doi:10.1038/nature02237. PMID 14724641. Bibcode: 2004Natur.427..256M. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity". Cancer Res. 65 (10): 3986–92. 2005. doi:10.1158/0008-5472.CAN-03-2334. PMID 15899786. 
• "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature 440 (7087): 1045–9. 2006. doi:10.1038/nature04689. PMID 16625196. Bibcode: 2006Natur.440.1045Z. 
• "Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region". Oncogene 25 (53): 7078–85. 2006. doi:10.1038/sj.onc.1209697. PMID 16732322. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.