Biology:LCMT2
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Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.[1][2][3]
The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G(1)/S and G(2)/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.[3]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. Aug 1998. doi:10.1093/dnares/5.1.31. PMID 9628581.
- ↑ "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf) 50 (50): 65–6. Dec 2006. doi:10.1093/nass/nrl032. PMID 17150819.
- ↑ 3.0 3.1 "Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9836.
Further reading
- "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry 38 (50): 16539–47. 2000. doi:10.1021/bi991646a. PMID 10600115.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells". Ann. N. Y. Acad. Sci. 973: 278–83. 2003. doi:10.1111/j.1749-6632.2002.tb04649.x. PMID 12485877.
- "p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1". Oncogene 22 (28): 4449–58. 2003. doi:10.1038/sj.onc.1206586. PMID 12853982.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders". Eur. J. Haematol. 74 (5): 424–9. 2005. doi:10.1111/j.1600-0609.2005.00417.x. PMID 15813917.
- "Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA". EMBO J. 25 (10): 2142–54. 2006. doi:10.1038/sj.emboj.7601105. PMID 16642040.
- "Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor". World J. Gastroenterol. 12 (26): 4161–5. 2006. doi:10.3748/wjg.v12.i26.4161. PMID 16830365.
- "p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1". Biochem. Biophys. Res. Commun. 350 (3): 662–8. 2006. doi:10.1016/j.bbrc.2006.09.092. PMID 17026958.
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