Biology:LCTL

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Further reading

• "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry 286 (50): 43294–300. December 2011. doi:10.1074/jbc.M111.267641. PMID 22020932. 
• "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases 24 (2): 83–100. June 1998. doi:10.1006/bcmd.1998.9998. PMID 9779294. https://zenodo.org/record/1229538. 
• "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1576 (3): 341–5. July 2002. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.