Biology:LUC7L3
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 Generic protein structure example |
LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.[1]
This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]
References
External links
- Human LUC7L3 genome location and LUC7L3 gene details page in the UCSC Genome Browser.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line.". FEBS Lett. 465 (2–3): 153–6. 2000. doi:10.1016/S0014-5793(99)01744-5. PMID 10631324.
- "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells.". J. Biomed. Sci. 7 (2): 152–9. 2000. doi:10.1007/BF02256622. PMID 10754390.
- "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. 2001. doi:10.1038/88107. PMID 11329013.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A.". Biochem. Biophys. Res. Commun. 301 (2): 324–9. 2003. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- "Binding specificity of Toll-like receptor cytoplasmic domains.". Eur. J. Immunol. 36 (3): 742–53. 2006. doi:10.1002/eji.200535158. PMID 16482509.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human.". Nucleic Acids Res. 35 (17): 5874–85. 2007. doi:10.1093/nar/gkm505. PMID 17726058.
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