Biology:Lipidome
The lipidome refers to the totality of lipids in cells. Lipids are one of the four major molecular components of biological organisms, along with proteins, sugars and nucleic acids. Lipidome is a term coined in the context of omics in modern biology, within the field of lipidomics.[2] It can be studied using mass spectrometry and bioinformatics as well as traditional lab-based methods.[3][4] The lipidome of a cell can be subdivided into the membrane-lipidome and mediator-lipidome.[5]
The first cell lipidome to be published was that of a mouse macrophage in 2010.[6] The lipidome of the yeast Saccharomyces cerevisiae has been characterised with an estimated 95% coverage;[7] studies of the human lipidome are ongoing.[2][6] For example, the human plasma lipidome consist of almost 600 distinct molecular species.[8] Research suggests that the lipidome of an individual may be able to indicate cancer risks associated with dietary fats, particularly breast cancer.[9][10]
See also
References
- ↑ Klose, C; Surma, MA.; Gerl, MJ.; Meyenhofer, F; Shevchenko, A; Simons, K (April 2012). "Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics". PLOS ONE 7 (4): e35063. doi:10.1371/journal.pone.0035063. PMID 22529973. Bibcode: 2012PLoSO...735063K.
- ↑ 2.0 2.1 "Lipidomics reveals a remarkable diversity of lipids in human plasma". J. Lipid Res. 51 (11): 3299–305. November 2010. doi:10.1194/jlr.M009449. PMID 20671299.
- ↑ Subramaniam S; Fahy E; Gupta S; Sud M; Byrnes R.W; Cotter D; Dinasarapu A.R; Maurya M.R (2011). "Bioinformatics and Systems Biology of the Lipidome". Chemical Reviews 111 (10): 6452–6490. doi:10.1021/cr200295k. PMID 21939287.
- ↑ "How to study lipidomes". J. Mol. Endocrinol. 42 (3): 185–90. March 2009. doi:10.1677/JME-08-0150. PMID 19060177.
- ↑ "Lipidomics". BioSoft. http://premierbiosoft.com/tech_notes/lipidomics.html.
- ↑ 6.0 6.1 "First Functioning 'Lipidome' of Mouse Macrophage Described". ScienceDaily. https://www.sciencedaily.com/releases/2010/12/101201142514.htm.
- ↑ "Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 106 (7): 2136–41. February 2009. doi:10.1073/pnas.0811700106. PMID 19174513.
- ↑ Quehenberger, Oswald; Dennis, Edward A. (2011-11-10). "The human plasma lipidome". The New England Journal of Medicine 365 (19): 1812–1823. doi:10.1056/NEJMra1104901. ISSN 1533-4406. PMID 22070478.
- ↑ "The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer". Prostaglandins Leukot. Essent. Fatty Acids 79 (3–5): 93–6. 2008. doi:10.1016/j.plefa.2008.09.004. PMID 18930643.
- ↑ "Diet, cancer, and the lipidome". Cancer Epidemiol. Biomarkers Prev. 15 (3): 416–21. March 2006. doi:10.1158/1055-9965.EPI-05-0546. PMID 16537692. PMC 2755770. http://www.hal.inserm.fr/inserm-00068759/document.
Further reading
- "Putting the 'Ome' in lipid metabolism". Biotechnol Annu Rev. Biotechnology Annual Review 12: 67–84. 2006. doi:10.1016/S1387-2656(06)12003-7. PMID 17045192.
- "Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome". Prog. Lipid Res. 49 (1): 1–26. January 2010. doi:10.1016/j.plipres.2009.07.003. PMID 19638285.
- "The emergence of yeast lipidomics". Biochim. Biophys. Acta 1771 (3): 241–54. March 2007. doi:10.1016/j.bbalip.2006.06.011. PMID 16920401.
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