Biology:List of adaptins
From HandWiki
Short description: none
Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes.[1] There are several types of adaptin, each related to a different AP complex.
Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.[1] The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):
- complex 1
- complex 2
- complex 3
- complex 4
- complex 5[2]
A diagram of the 5 complexes is shown here
References
- ↑ 1.0 1.1 Boehm, Markus; Bonifacino, Juan S. (October 2001). "Adaptins". Molecular Biology of the Cell 12 (10): 2907–2920. doi:10.1091/mbc.12.10.2907. ISSN 1059-1524. PMID 11598180.
- ↑ Mattera, Rafael; Guardia, Carlos M.; Sidhu, Sachdev S.; Bonifacino, Juan S. (2015). "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal of Biological Chemistry 290 (52): 30736–30749. doi:10.1074/jbc.M115.683409. PMID 26542808.
- Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
- Hirst, J. D.Expression error: Unrecognized word "et". (2011). "The Fifth Adaptor Protein Complex". PLOS Biology 9 (10). doi:10.1371/journal.pbio.1001170. PMID 22022230.
 |  |
