Biology:Low-density-lipoprotein receptor kinase
low-density lipoprotein kinase | |||||||||
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Identifiers | |||||||||
EC number | 2.7.11.29 | ||||||||
CAS number | 107445-00-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a low-density-lipoprotein receptor kinase (EC 2.7.11.29) is an enzyme that catalyzes the chemical reaction
- ATP + [low-density-lipoprotein receptor]-L-serine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
Thus, the two substrates of this enzyme are ATP and [low-density-lipoprotein receptor]-L-serine, whereas its two products are ADP and [low-density-lipoprotein receptor]-O-phospho-L-serine.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase. Other names in common use include ATP:low-density-lipoprotein-L-serine O-phosphotransferase, LDL receptor kinase, [low-density-lipoprotein] kinase, low-density lipoprotein kinase, low-density-lipoprotein receptor kinase (phosphorylating), and STK7.
References
- "Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II". J. Biol. Chem. 262 (3): 1344–51. 1987. PMID 3100530.
- "Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein". J. Biol. Chem. 262 (19): 9367–73. 1987. PMID 3597414.
![]() | Original source: https://en.wikipedia.org/wiki/Low-density-lipoprotein receptor kinase.
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