Biology:MAP2K6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.[1]
Function
MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.[2]
Interactions
MAP2K6 has been shown to interact with TAOK2,[3] ASK1,[4][5] MAPK14[3][6][7][8] and MAP3K7.[9][10][11][12]
References
- ↑ "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)". The Journal of Biological Chemistry 271 (6): 2886–91. Feb 1996. doi:10.1074/jbc.271.6.2886. PMID 8621675.
- ↑ "Entrez Gene: MAP2K6 mitogen-activated protein kinase kinase 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5608.
- ↑ 3.0 3.1 "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry 276 (19): 16070–5. May 2001. doi:10.1074/jbc.M100681200. PMID 11279118.
- ↑ "Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)". Molecular Cell 11 (6): 1491–501. Jun 2003. doi:10.1016/S1097-2765(03)00180-1. PMID 12820963.
- ↑ "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal 20 (21): 6028–36. Nov 2001. doi:10.1093/emboj/20.21.6028. PMID 11689443.
- ↑ "p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels". Molecular and Cellular Biology 23 (9): 3079–90. May 2003. doi:10.1128/MCB.23.9.3079-3090.2003. PMID 12697810.
- ↑ "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway". Molecular and Cellular Biology 16 (3): 1247–55. Mar 1996. doi:10.1128/mcb.16.3.1247. PMID 8622669.
- ↑ "Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade". The Journal of Biological Chemistry 271 (19): 11427–33. May 1996. doi:10.1074/jbc.271.19.11427. PMID 8626699.
- ↑ "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". The EMBO Journal 22 (23): 6277–88. Dec 2003. doi:10.1093/emboj/cdg605. PMID 14633987.
- ↑ "TAK1 is a ubiquitin-dependent kinase of MKK and IKK". Nature 412 (6844): 346–51. Jul 2001. doi:10.1038/35085597. PMID 11460167. Bibcode: 2001Natur.412..346W.
- ↑ "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature 398 (6724): 252–6. Mar 1999. doi:10.1038/18465. PMID 10094049. Bibcode: 1999Natur.398..252N.
- ↑ "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Letters 474 (2–3): 141–5. Jun 2000. doi:10.1016/S0014-5793(00)01588-X. PMID 10838074.
Further reading
- "Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2". Current Biology 8 (19): 1049–57. Sep 1998. doi:10.1016/S0960-9822(98)70442-7. PMID 9768359.
- "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system". Immunological Reviews 208: 30–49. Dec 2005. doi:10.1111/j.0105-2896.2005.00327.x. PMID 16313339.
- "Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells". FEBS Letters 364 (2): 223–8. May 1995. doi:10.1016/0014-5793(95)00346-B. PMID 7750576.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway". Molecular and Cellular Biology 16 (3): 1247–55. Mar 1996. doi:10.1128/mcb.16.3.1247. PMID 8622669.
- "Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade". The Journal of Biological Chemistry 271 (19): 11427–33. May 1996. doi:10.1074/jbc.271.19.11427. PMID 8626699.
- "A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3". The Journal of Biological Chemistry 271 (23): 13675–9. Jun 1996. doi:10.1074/jbc.271.23.13675. PMID 8663074.
- "Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells". The EMBO Journal 15 (16): 4156–64. Aug 1996. doi:10.1002/j.1460-2075.1996.tb00790.x. PMID 8861944.
- "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". The EMBO Journal 16 (12): 3563–71. Jun 1997. doi:10.1093/emboj/16.12.3563. PMID 9218798.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6". The Journal of Biological Chemistry 273 (3): 1741–8. Jan 1998. doi:10.1074/jbc.273.3.1741. PMID 9430721.
- "Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades". The Biochemical Journal 336 (Pt 3): 599–609. Dec 1998. doi:10.1042/bj3360599. PMID 9841871.
- "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". The Journal of Biological Chemistry 274 (40): 28803–7. Oct 1999. doi:10.1074/jbc.274.40.28803. PMID 10497253.
- "c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13819–24. Nov 1999. doi:10.1073/pnas.96.24.13819. PMID 10570156. Bibcode: 1999PNAS...9613819C.
- "Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest". Molecular and Cellular Biology 20 (13): 4543–52. Jul 2000. doi:10.1128/MCB.20.13.4543-4552.2000. PMID 10848581.
- "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity". Blood 96 (5): 1844–52. Sep 2000. doi:10.1182/blood.V96.5.1844. PMID 10961885.
- "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7". The Biochemical Journal 352 Pt 1 (Pt 1): 145–54. Nov 2000. doi:10.1042/0264-6021:3520145. PMID 11062067.
- "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor". The Biochemical Journal 352 Pt 3 (Pt 3): 739–45. Dec 2000. doi:10.1042/0264-6021:3520739. PMID 11104681.
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