Biology:MAP3K10

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[3]

Interactions

MAP3K10 has been shown to interact with:

References

  1. "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem 234 (2): 492–500. February 1996. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694. 
  2. "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene 10 (7): 1447–51. May 1995. PMID 7731697. 
  3. 3.0 3.1 "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294. 
  4. 4.0 4.1 "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. January 1998. doi:10.1093/emboj/17.1.149. PMID 9427749. 
  5. "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. June 2000. doi:10.1074/jbc.C000180200. PMID 10801775. 
  6. 6.0 6.1 "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. October 1999. doi:10.1128/mcb.19.10.7245. PMID 10490659. 
  7. "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9578–83. August 2003. doi:10.1073/pnas.1133382100. PMID 12881483. Bibcode2003PNAS..100.9578M. 

Further reading