Biology:MAP3K13
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.[1][2]
Function
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.[2]
Interactions
MAP3K13 has been shown to interact with PRDX3.[3]
References
- ↑ "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem 272 (45): 28622–9. Dec 1997. doi:10.1074/jbc.272.45.28622. PMID 9353328.
- ↑ 2.0 2.1 "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9175.
- ↑ "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. Jan 2003. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.
Further reading
- "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. 2003. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.
- "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. 2002. doi:10.1080/10258140290027243. PMID 12186766.
- "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. 2002. doi:10.1093/oxfordjournals.jbchem.a003048. PMID 11726277.
- "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. 2001. doi:10.1016/S0014-5793(00)02432-7. PMID 11163770.
- "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. 1994. PMID 8274451.
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