Biology:MARCH2
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E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene.[1][2][3] It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins.[4] MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.[5]
Gene name error in Excel
Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel.[6] This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.[7] The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.
References
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. October 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". Journal of Virology 78 (3): 1109–20. February 2004. doi:10.1128/JVI.78.3.1109-1120.2004. PMID 14722266.
- ↑ "Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51257.
- ↑ "MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation". Virology 518: 293–300. May 2018. doi:10.1016/j.virol.2018.02.003. PMID 29573664.
- ↑ Chathuranga, Kiramage; Kim, Tae-Hwan; Lee, Hyuncheol; Park, Jun-Seol; Kim, Jae-Hoon; Chathuranga, Wijesinghe A Gayan; Ekanayaka, Pathum; Choi, Youn Jung et al. (2020). "Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2". The EMBO Journal 39 (21). doi:10.15252/embj.2020105139. PMID 32935379.
- ↑ "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics 5 (1). June 2004. doi:10.1186/1471-2105-5-80. PMID 15214961.
- ↑ "Gene name errors are widespread in the scientific literature". Genome Biology 17 (1). August 2016. doi:10.1186/s13059-016-1044-7. PMID 27552985.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. April 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. April 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. June 2004. doi:10.1038/nbt971. PMID 15146197.
- "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking". Molecular Biology of the Cell 16 (4): 1696–710. April 2005. doi:10.1091/mbc.E04-03-0216. PMID 15689499.
- "MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II". Journal of Biochemistry 139 (1): 137–45. January 2006. doi:10.1093/jb/mvj012. PMID 16428329. https://zenodo.org/record/895647.
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