Biology:MARK4

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[1][2][3] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.[4] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.[5]

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease.

Interactions

MARK4 has been shown to interact with USP9X[6] and Ubiquitin C.[6]

References

  1. ↑ "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia 3 (1): 4–9. Apr 2001. doi:10.1038/sj.neo.7900132. PMID 11326310. 
  2. ↑ "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. April 1997. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484. 
  3. ↑ "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57787. 
  4. ↑ "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. April 1997. doi:10.1016/s0092-8674(00)80208-1. PMID 9108484. 
  5. ↑ "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics 67 (2): 485–99. November 2013. doi:10.1007/s12013-013-9550-7. PMID 23471664. 
  6. ↑ 6.0 6.1 "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". The Biochemical Journal 411 (2): 249–60. April 2008. doi:10.1042/BJ20080067. PMID 18254724. https://hal.archives-ouvertes.fr/hal-00478950/file/PEER_stage2_10.1042%252FBJ20080067.pdf. 

Further reading

  • "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 8 (2): 85–95. April 2001. doi:10.1093/dnares/8.2.85. PMID 11347906. 
  • "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines". Oncogene 22 (17): 2581–91. May 2003. doi:10.1038/sj.onc.1206336. PMID 12735302. 
  • "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". The Journal of Biological Chemistry 279 (7): 5915–23. February 2004. doi:10.1074/jbc.M304528200. PMID 14594945. 
  • "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry 279 (13): 12804–11. March 2004. doi:10.1074/jbc.M312171200. PMID 14676191. 
  • "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4". Journal of Neurochemistry 88 (5): 1114–26. March 2004. doi:10.1046/j.1471-4159.2003.02228.x. PMID 15009667. 
  • "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
  • "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics 6 (3): 537–47. March 2007. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 




Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:MARK4&oldid=3664151"