Biology:MED27
 Generic protein structure example |
| Med27 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med27 | ||||||||
| Pfam | PF11571 | ||||||||
| InterPro | IPR021627 | ||||||||
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Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene.[1][2] It forms part of the Mediator complex.
The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.[3]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[2]
See also
References
- ↑ "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature 397 (6718): 446–50. Feb 1999. doi:10.1038/17141. PMID 9989412. Bibcode: 1999Natur.397..446R.
- ↑ 2.0 2.1 "Entrez Gene: CRSP8 cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9442.
- ↑ "Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development". Genetics 174 (2): 693–705. October 2006. doi:10.1534/genetics.105.055152. PMID 16582438.
Further reading
- "[Relation between manifest bronchial obstruction and bronchial hyperreactivity (author's transl)]". Zeitschrift für Erkrankungen der Atmungsorgane 146 (1): 12–6. 1977. PMID 1020353.
- "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. 1996. PMID 8895530.
- "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.". Mol. Cell 5 (4): 753–60. 2000. doi:10.1016/S1097-2765(00)80254-3. PMID 10882111.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123–7. 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
- "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. 2004. doi:10.1074/jbc.C300444200. PMID 14576168.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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