Biology:MED28
 Generic protein structure example |
| Med28 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med28 | ||||||||
| Pfam | PF11594 | ||||||||
| InterPro | IPR021640 | ||||||||
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Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[1][2][3] It forms part of the Mediator complex.
Function
Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[4]
Interactions
MED28 has been shown to interact with Merlin,[2] Grb2[2] and MED26.[5]
See also
References
- ↑ "Identification of a novel endothelial-derived gene EG-1". Biochemical and Biophysical Research Communications 290 (1): 602–12. Jan 2002. doi:10.1006/bbrc.2001.6119. PMID 11779215.
- ↑ 2.0 2.1 2.2 "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene 23 (54): 8815–25. Nov 2004. doi:10.1038/sj.onc.1208110. PMID 15467741.
- ↑ "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80306.
- ↑ "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry 282 (44): 32152–7. Nov 2007. doi:10.1074/jbc.M706592200. PMID 17848560.
- ↑ "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. Jun 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Further reading
- "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research 11 (10): 1758–65. Oct 2001. doi:10.1101/gr.180101. PMID 11591653.
- "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. Apr 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. Feb 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
- "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. Jun 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- "The novel gene EG-1 stimulates cellular proliferation". Cancer Research 65 (14): 6159–66. Jul 2005. doi:10.1158/0008-5472.CAN-04-4016. PMID 16024617.
- "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation". Biochemical and Biophysical Research Communications 348 (3): 826–31. Sep 2006. doi:10.1016/j.bbrc.2006.07.126. PMID 16899217.
- "EG-1 interacts with c-Src and activates its signaling pathway". International Journal of Oncology 29 (4): 1013–8. Oct 2006. doi:10.3892/ijo.29.4.1013. PMID 16964398.
- "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry 282 (44): 32152–7. Nov 2007. doi:10.1074/jbc.M706592200. PMID 17848560.
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