Biology:MED31
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| Med31 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med31 | ||||||||
| Pfam | PF05669 | ||||||||
| InterPro | IPR008831 | ||||||||
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Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.[1][2] It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant[3] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.[4]
References
- ↑ "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–713. Aug 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- ↑ "Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51003.
- ↑ "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae". Genetics 137 (4): 945–56. August 1994. doi:10.1093/genetics/137.4.945. PMID 7982575.
- ↑ "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae". Genetics 142 (3): 749–59. March 1996. doi:10.1093/genetics/142.3.749. PMID 8849885.
Further reading
- Gu W; Malik S; Ito M et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
- Suzuki H; Fukunishi Y; Kagawa I et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–1765. doi:10.1101/gr.180101. PMID 11591653.
- Brower CS; Sato S; Tomomori-Sato C et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–10358. doi:10.1073/pnas.162424199. PMID 12149480. Bibcode: 2002PNAS...9910353B.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Sato S; Tomomori-Sato C; Banks CA et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. doi:10.1074/jbc.C300054200. PMID 12584197.
- Sato S; Tomomori-Sato C; Banks CA et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. doi:10.1074/jbc.C300444200. PMID 14576168.
- Tomomori-Sato C; Sato S; Parmely TJ et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. doi:10.1074/jbc.M312523200. PMID 14638676.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Sato S; Tomomori-Sato C; Parmely TJ et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–691. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Goehler H; Lalowski M; Stelzl U et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Stelzl U; Worm U; Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
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