Biology:MED8
From HandWiki
 Generic protein structure example |
Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.[1][2][3]
Function
This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.[3]
Interactions
MED8 has been shown to interact with MED26.[4]
References
- ↑ "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc Natl Acad Sci U S A 99 (16): 10353–8. Aug 2002. doi:10.1073/pnas.162424199. PMID 12149480. Bibcode: 2002PNAS...9910353B.
- ↑ "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A 95 (15): 8538–43. Aug 1998. doi:10.1073/pnas.95.15.8538. PMID 9671713. Bibcode: 1998PNAS...95.8538J.
- ↑ 3.0 3.1 "Entrez Gene: MED8 mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112950.
- ↑ "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–91. Jun 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Further reading
- "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–32. 1999. doi:10.1038/19789. PMID 10235267. Bibcode: 1999Natur.398..828N.
- "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. 2002. doi:10.1073/pnas.241522398. PMID 11752456.
- "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. 2003. doi:10.1074/jbc.C300054200. PMID 12584197.
- "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. 2004. doi:10.1074/jbc.C300444200. PMID 14576168.
- "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. 2004. doi:10.1074/jbc.M312523200. PMID 14638676.
- "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–91. 2004. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- "Interaction of Bunyamwera Orthobunyavirus NSs Protein with Mediator Protein MED8: a Mechanism for Inhibiting the Interferon Response". J. Virol. 80 (19): 9667–75. 2006. doi:10.1128/JVI.00822-06. PMID 16973571.
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