Biology:MESTIT1 (gene)
From HandWiki
In molecular biology, MEST intronic transcript 1, antisense RNA (non-protein coding), also known as MESTIT1 or PEG1-AS is a long non-coding RNA. It is an imprinted gene, which is paternally expressed.[1] In humans, it is found on chromosome 7q32, imprinted genes on chromosome 7 are believed to be involved in Russell-Silver syndrome (RSS). However, it is believed that MESTIT1 is unlikely to cause Russell-Silver syndrome as there is a lack of mutations in this gene in Russell-Silver syndrome patients.[1][2][3][4] MESTIT1 may regulate the expression of the MEST gene.[1]
See also
- Long noncoding RNA
References
- ↑ 1.0 1.1 1.2 "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32.". Hum Mol Genet 11 (15): 1743–1756. 2002. doi:10.1093/hmg/11.15.1743. PMID 12095916.
- ↑ "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.". J Med Genet 40 (4): 249–256. 2003. doi:10.1136/jmg.40.4.249. PMID 12676894.
- ↑ "Evidence against a major role of PEG1/MEST in Silver-Russell syndrome.". Eur J Hum Genet 6 (2): 114–120. 1998. doi:10.1038/sj.ejhg.5200164. PMID 9781054.
- ↑ "No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients.". Am J Med Genet 104 (3): 225–231. 2001. doi:10.1002/ajmg.10022. PMID 11754049. https://pubmed.ncbi.nlm.nih.gov/11754049.
Further reading
- "Searching for genomic variants in the MESTIT1 transcript in Silver-Russell syndrome patients.". J Med Genet 40 (5): 65e–65. 2003. doi:10.1136/jmg.40.5.e65. PMID 12746419.
- "Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.". Genomics 83 (3): 402–412. 2004. doi:10.1016/j.ygeno.2003.08.016. PMID 14962666. https://pubmed.ncbi.nlm.nih.gov/14962666.
- "Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines.". Genome Res 17 (12): 1731–1742. 2007. doi:10.1101/gr.6609207. PMID 17989250.
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