Biology:MIR223

Short description: Non-coding RNA in the species Homo sapiens

Generic protein structure example

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• "Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein". Cancer Cell 12 (5): 457–66. November 2007. doi:10.1016/j.ccr.2007.09.020. PMID 17996649. 
• "Potential role of miR-9 and miR-223 in recurrent ovarian cancer". Mol. Cancer 7. April 2008. doi:10.1186/1476-4598-7-35. PMID 18442408. 
• "MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1". Gastroenterology 135 (1): 257–69. July 2008. doi:10.1053/j.gastro.2008.04.003. PMID 18555017. 
• "MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells". J. Cell. Mol. Med. 13 (11–12): 4551–9. 2009. doi:10.1111/j.1582-4934.2008.00585.x. PMID 19017354. 
• "Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas". Blood 113 (16): 3754–64. April 2009. doi:10.1182/blood-2008-10-184077. PMID 19047678. 
• "Novel genetic variants in microRNA genes and familial breast cancer". Int. J. Cancer 124 (5): 1178–82. March 2009. doi:10.1002/ijc.24008. PMID 19048628. 
• "microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification". Blood 113 (21): 5237–45. May 2009. doi:10.1182/blood-2008-11-189407. PMID 19144983. 
• "Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia". Leukemia 23 (4): 746–52. April 2009. doi:10.1038/leu.2008.370. PMID 19148136. 
• "MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis". Haematologica 94 (4): 479–86. April 2009. doi:10.3324/haematol.2008.002345. PMID 19278969. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.