Biology:MKI67IP

From HandWiki
Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example
FHA Ki67 binding domain of hNIFK
PDB 2aff EBI.jpg
the solution structure of the ki67fha/hnifk(226-269)3p complex
Identifiers
SymbolhNIFK_binding
PfamPF12196
InterProIPR021043

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.[1][2]

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.[3]

References

  1. "A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis". J Biol Chem 276 (27): 25386–91. Jul 2001. doi:10.1074/jbc.M102227200. PMID 11342549. 
  2. "Entrez Gene: MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84365. 
  3. "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67". Nat. Struct. Mol. Biol. 12 (11): 987–93. November 2005. doi:10.1038/nsmb1008. PMID 16244663. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)


This article incorporates text from the public domain Pfam and InterPro: IPR021043