Biology:MST4
 Generic protein structure example |
Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.[1]
Function
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[1]
Interactions
RP6-213H19.1 has been shown to interact with:
References
- ↑ 1.0 1.1 "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51765.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics 8 (1): 157–71. January 2009. doi:10.1074/mcp.M800266-MCP200. PMID 18782753.
Further reading
- "[Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)]". Archiv der Pharmazie 308 (7): 564–70. 1975. doi:10.1002/ardp.19753080712. PMID 1164178.
- "Cloning and characterization of MST4, a novel Ste20-like kinase". J. Biol. Chem. 276 (25): 22439–45. 2001. doi:10.1074/jbc.M009323200. PMID 11306563.
- "The Ste20 group kinases as regulators of MAP kinase cascades". Trends Cell Biol. 11 (5): 220–30. 2001. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
- "MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway". Oncogene 20 (45): 6559–69. 2001. doi:10.1038/sj.onc.1204818. PMID 11641781.
- "Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties". J. Biol. Chem. 277 (8): 5929–39. 2002. doi:10.1074/jbc.M110882200. PMID 11741893.
- "The Ste20 kinase MST4 plays a role in prostate cancer progression". Cancer Res. 63 (12): 3356–63. 2003. PMID 12810671.
- "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J. Cell Biol. 164 (7): 1009–20. 2004. doi:10.1083/jcb.200310061. PMID 15037601.
- "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene 24 (12): 2076–86. 2005. doi:10.1038/sj.onc.1208445. PMID 15688006.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway". Mol. Biol. Cell 18 (6): 1965–78. 2007. doi:10.1091/mbc.E06-07-0608. PMID 17360971.
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