Biology:Mir-25 microRNA precursor family

mir-25
Identifiers
Symbol	mir-25
Rfam	RF02020
miRBase family	25
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.

See also

• MicroRNA

Further reading

• "Ginsenoside Rb₁ induces type I collagen expression through peroxisome proliferator-activated receptor-delta". Biochemical Pharmacology 84 (4): 532–9. August 2012. doi:10.1016/j.bcp.2012.05.023. PMID 22692056. 
• "Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters". Clinical Cancer Research 18 (11): 3054–70. June 2012. doi:10.1158/1078-0432.CCR-11-1078. PMID 22452939. 
• "MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma". Biochemical and Biophysical Research Communications 421 (4): 640–5. May 2012. doi:10.1016/j.bbrc.2012.03.048. PMID 22450326. 
• "MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme". Proceedings of the National Academy of Sciences of the United States of America 109 (14): 5316–21. April 2012. doi:10.1073/pnas.1202465109. PMID 22431589. 
• "Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2". The Journal of Clinical Endocrinology and Metabolism 97 (5): E710-8. May 2012. doi:10.1210/jc.2011-3068. PMID 22399519. 
• "Analysis of serum genome-wide microRNAs for breast cancer detection". Clinica Chimica Acta; International Journal of Clinical Chemistry 413 (13–14): 1058–65. July 2012. doi:10.1016/j.cca.2012.02.016. PMID 22387599. 
• "REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility". Oncogene 32 (2): 242–50. January 2013. doi:10.1038/onc.2012.32. PMID 22349819. 
• "Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls". Carcinogenesis 33 (4): 828–34. April 2012. doi:10.1093/carcin/bgs030. PMID 22298638. 
• "The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms". Journal of Molecular Medicine 90 (6): 667–79. June 2012. doi:10.1007/s00109-011-0844-1. PMID 22215152. 
• "MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer". Oncology Reports 27 (2): 594–8. February 2012. doi:10.3892/or.2011.1530. PMID 22076535. 
• Bellusci, Saverio, ed (2011). "A systematic screen for micro-RNAs regulating the canonical Wnt pathway". PLOS ONE 6 (10): e26257. doi:10.1371/journal.pone.0026257. PMID 22043311. 
• "[MicroRNA expression pattern in intraductal papillary mucinous neoplasm]". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi 58 (4): 190–200. October 2011. doi:10.4166/kjg.2011.58.4.190. PMID 22042419. 
• "miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma". Hepatology 55 (2): 465–75. February 2012. doi:10.1002/hep.24698. PMID 21953056. 
• "MicroRNA expression profiles in the progression of prostate cancer--from high-grade prostate intraepithelial neoplasia to metastasis". Urologic Oncology 31 (6): 796–801. August 2013. doi:10.1016/j.urolonc.2011.07.002. PMID 21880514. 
• "MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells". American Journal of Cancer Research 1 (5): 574–584. 2011. PMID 21796275. 
• "miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3". Molecular Cancer Research 9 (7): 824–33. July 2011. doi:10.1158/1541-7786.MCR-10-0529. PMID 21628394. 
• "Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain". BMC Genomics 12 (1): 277. May 2011. doi:10.1186/1471-2164-12-277. PMID 21627805. 
• "The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation". Aging 3 (2): 108–24. February 2011. doi:10.18632/aging.100285. PMID 21386132. 
• "Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation". Physiological Genomics 43 (9): 479–87. May 2011. doi:10.1152/physiolgenomics.00222.2010. PMID 21266501. 
• "The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning". Developmental Biology 351 (2): 254–65. March 2011. doi:10.1016/j.ydbio.2011.01.005. PMID 21256124. 
• "MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression". International Journal of Immunopathology and Pharmacology 23 (4): 1229–34. 2010. doi:10.1177/039463201002300427. PMID 21244772. 
• "Survey of MicroRNA expression in pediatric brain tumors". Pediatric Blood & Cancer 56 (2): 211–6. February 2011. doi:10.1002/pbc.22723. PMID 21157891. 
• "Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma". Cancer Research 70 (23): 9798–807. December 2010. doi:10.1158/0008-5472.CAN-10-1001. PMID 21098710. 
• "MicroRNA regulation of ionizing radiation-induced premature senescence". International Journal of Radiation Oncology, Biology, Physics 81 (3): 839–48. November 2011. doi:10.1016/j.ijrobp.2010.09.048. PMID 21093163. 
• "Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy". American Journal of Nephrology 32 (6): 581–9. 2010. doi:10.1159/000322105. PMID 21071935. 
• "Negative regulation of the tumor suppressor p53 gene by microRNAs". Oncogene 30 (7): 843–53. February 2011. doi:10.1038/onc.2010.457. PMID 20935678. 
• "miRNA expression profiling of lung adenocarcinomas: correlation with mutational status". Modern Pathology 23 (12): 1577–82. December 2010. doi:10.1038/modpathol.2010.152. PMID 20818338. 
• "Altered miRNA expression in T regulatory cells in course of multiple sclerosis". Journal of Neuroimmunology 226 (1–2): 165–71. September 2010. doi:10.1016/j.jneuroim.2010.06.009. PMID 20637509. 
• "Fragile X protein family member FXR1P is regulated by microRNAs". RNA 16 (8): 1530–9. August 2010. doi:10.1261/rna.2022210. PMID 20519410. 
• "Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation". Science Signaling 3 (117): ra29. April 2010. doi:10.1126/scisignal.2000594. PMID 20388916. 
• "MicroRNAs expression signatures are associated with lineage and survival in acute leukemias". Blood Cells, Molecules & Diseases 44 (3): 191–7. March 2010. doi:10.1016/j.bcmd.2009.12.010. PMID 20110180. 
• "MicroRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca (Lama pacos) skin melanocytes". Domestic Animal Endocrinology 38 (3): 200–9. April 2010. doi:10.1016/j.domaniend.2009.10.004. PMID 20036482. 
• "Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading". Circulation: Heart Failure 2 (6): 633–42. November 2009. doi:10.1161/CIRCHEARTFAILURE.108.823070. PMID 19919989. 
• "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs". Science Signaling 2 (94): ra69. October 2009. doi:10.1126/scisignal.2000442. PMID 19861690. 
• "Identification and functional characterization of microRNAs involved in the malignant progression of gliomas". Brain Pathology 20 (3): 539–50. May 2010. doi:10.1111/j.1750-3639.2009.00328.x. PMID 19775293. 
• "MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype". American Journal of Respiratory Cell and Molecular Biology 42 (4): 506–13. April 2010. doi:10.1165/rcmb.2009-0123OC. PMID 19541842. 
• "Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma". Cancer Science 100 (7): 1234–42. July 2009. doi:10.1111/j.1349-7006.2009.01164.x. PMID 19486339. 
• "The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim". Gastroenterology 136 (5): 1689–700. May 2009. doi:10.1053/j.gastro.2009.02.002. PMID 19422085. 
• "Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer". Nucleic Acids Research 37 (5): 1672–81. April 2009. doi:10.1093/nar/gkp002. PMID 19153141. 
• "MicroRNA expression profile of bronchioalveolar stem cells from mouse lung". Biochemical and Biophysical Research Communications 377 (2): 668–673. December 2008. doi:10.1016/j.bbrc.2008.10.052. PMID 18948085. 
• "Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs". Gene Therapy 15 (23): 1536–49. December 2008. doi:10.1038/gt.2008.147. PMID 18800151. 
• "PerioGlas regulates osteoblast RNA interfering". Journal of Prosthodontics 17 (7): 522–6. October 2008. doi:10.1111/j.1532-849X.2008.00331.x. PMID 18573151. 
• "Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members". The Journal of Biological Chemistry 282 (46): 33632–40. November 2007. doi:10.1074/jbc.M705116200. PMID 17848567. 
• "Differences in osteoblast miRNA induced by cell binding domain of collagen and silicate-based synthetic bone". Journal of Biomedical Science 14 (6): 777–82. November 2007. doi:10.1007/s11373-007-9193-z. PMID 17653614. 
• "Molecular evolution of a microRNA cluster". Journal of Molecular Biology 339 (2): 327–35. May 2004. doi:10.1016/j.jmb.2004.03.065. PMID 15136036. 

External links

• Page for mir-25 microRNA precursor family at Rfam