Biology:miRBase
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| Content | |
| Description | microRNA database |
| Contact | |
| Research centre | University of Manchester |
| Author(s) | Ana Kozomara |
| Primary citation | Kozomara & al. (2011)[1] |
| Release date | 2010 |
| Access | |
| Website | www |
In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations.[1][2][3][4] As of September 2010 it contained information about 15,172 microRNAs.[1] This number has risen to 38,589 by March 2018.[5] The miRBase registry provides a centralised system for assigning new names to microRNA genes.[6]
miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003.[7]
According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims:[1]
- To provide a consistent naming system for microRNAs
- To provide a central place collecting all known microRNA sequences
- To provide human and computer readable information for each microRNA
- To provide primary evidence for each microRNA
- To aggregate and link to microRNA target information
MiRBase contains miRNAs belonging of various species belonging to Alveolata, Chromalveolata, Metazoa, Mycetozoa, Viridiplantae and Viruses. For the Viridiplantae, in release 21 (2014) data is available for 73 species. This includes 4800 unique mature miRNAs and 8480 precursor sequences.[8]
The current version of MiRBase is release 22 (March 2018).
References
- ↑ 1.0 1.1 1.2 1.3 Kozomara, A.; Griffiths-Jones, S. (2010). "MiRBase: integrating microRNA annotation and deep-sequencing data". Nucleic Acids Research 39 (Database issue): D152–7. doi:10.1093/nar/gkq1027. PMID 21037258.
- ↑ Griffiths-Jones, Sam (2010). "MiRBase: microRNA Sequences and Annotation". Current Protocols in Bioinformatics. Chapter 12. pp. Unit 12.9.1–10. doi:10.1002/0471250953.bi1209s29. ISBN 978-0471250951.
- ↑ Griffiths-Jones, S.; Saini, H. K.; Van Dongen, S.; Enright, A. J. (2007). "MiRBase: tools for microRNA genomics". Nucleic Acids Research 36 (Database issue): D154–8. doi:10.1093/nar/gkm952. PMID 17991681.
- ↑ Griffiths-Jones, Sam (2006). "MiRBase: the MicroRNA Sequence Database". MicroRNA Protocols. Methods in Molecular Biology. 342. pp. 129–38. doi:10.1385/1-59745-123-1:129. ISBN 1-59745-123-1.
- ↑ "Mirbase 22 Release Notes". ftp://mirbase.org/pub/mirbase/CURRENT/README.
- ↑ Griffiths-Jones, S.; Grocock, RJ; Van Dongen, S; Bateman, A; Enright, AJ (2006). "MiRBase: microRNA sequences, targets and gene nomenclature". Nucleic Acids Research 34 (Database issue): D140–4. doi:10.1093/nar/gkj112. PMID 16381832.
- ↑ Griffiths-Jones S (January 2004). "The microRNA Registry". Nucleic Acids Res. 32 (Database issue): D109–11. doi:10.1093/nar/gkh023. PMID 14681370.
- ↑ Nithin, Chandran; Thomas, Amal; Basak, Jolly; Bahadur, Ranjit Prasad (2017-11-15). "Genome-wide identification of miRNAs and lncRNAs in Cajanus cajan". BMC Genomics 18 (1): 878. doi:10.1186/s12864-017-4232-2. ISSN 1471-2164. PMID 29141604.
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