Biology:Mir-638 microRNA precursor family
From HandWiki
| mir-638 | |
|---|---|
| Identifiers | |
| Symbol | mir-638 |
| Rfam | RF00978 |
| miRBase family | MIPF0000486 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-638 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Expression in lupus nephritis
miR-638 has been implicated in the pathogenesis of lupus nephritis (LN), with intra-renal expression levels differing between normal and lupus nephritis patients.[1] The degree of difference in expression levels further correlates with the degree of disease severity in each LN patient.
miR-638 and gastric cancer
miR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs.[2] Thus miR-628 is likely to be involved in the development and progression of gastric cancer.
Further applications
miR-638 has additionally been found to be upregulated in the K562 leukaemic cell line.[3]
See also
References
- ↑ "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology 17 (4): 346–51. May 2012. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894. https://pubmed.ncbi.nlm.nih.gov/22295894.
- ↑ "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports 2 (6): 963–70. 2009. doi:10.3892/mmr_00000199. PMID 21475928.
- ↑ "[Expression level of miRNA-663 in different leukemic cell lines and its biological function"]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 19 (2): 279–83. April 2011. PMID 21518471. https://pubmed.ncbi.nlm.nih.gov/21518471.
Further reading
- "Microparticle conferred microRNA profiles--implications in the transfer and dominance of cancer traits". Molecular Cancer 11 (1): 37. June 2012. doi:10.1186/1476-4598-11-37. PMID 22682234.
- "miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes". Carcinogenesis 33 (7): 1294–301. July 2012. doi:10.1093/carcin/bgs179. PMID 22610076.
- "Discrepant expression of microRNAs in transparent and cataractous human lenses". Investigative Ophthalmology & Visual Science 53 (7): 3906–12. June 2012. doi:10.1167/iovs.11-9178. PMID 22562507.
- "Expression of microRNAs in basal cell carcinoma". The British Journal of Dermatology 167 (4): 847–55. October 2012. doi:10.1111/j.1365-2133.2012.11022.x. PMID 22540308.
- "Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation". Toxicological Sciences 125 (2): 382–91. February 2012. doi:10.1093/toxsci/kfr299. PMID 22048643.
- "Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs". Hypertension 58 (6): 1093–8. December 2011. doi:10.1161/HYPERTENSIONAHA.111.180729. PMID 22042811.
- "Invasion front-specific expression and prognostic significance of microRNA in colorectal liver metastases". Cancer Science 102 (10): 1799–807. October 2011. doi:10.1111/j.1349-7006.2011.02023.x. PMID 21722265.
- "[Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia]". Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi 32 (3): 178–81. March 2011. PMID 21535956.
- Means, Terry, ed (May 2010). "Identification of unique microRNA signature associated with lupus nephritis". PLOS ONE 5 (5): e10344. doi:10.1371/journal.pone.0010344. PMID 20485490. Bibcode: 2010PLoSO...510344T.
- "Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells". Virology 398 (1): 57–67. March 2010. doi:10.1016/j.virol.2009.11.036. PMID 20006370.
- "Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology 221 (1): 109–19. October 2009. doi:10.1002/jcp.21834. PMID 19475566.
- Jones, Chris, ed (2009). "Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients". PLOS ONE 4 (5): e5532. doi:10.1371/journal.pone.0005532. PMID 19440243. Bibcode: 2009PLoSO...4.5532T.
External links
 |  |
