Biology:Mir-650 microRNA precursor family
From HandWiki
| mir-650 | |
|---|---|
| Identifiers | |
| Symbol | mir-650 |
| Rfam | RF00952 |
| miRBase family | MIPF0000457 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Diabetic and Non-Diabetic Heart Failure
miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions.[1]
NDRG2 regulation
miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene.[2] There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.
See also
References
- ↑ "MicroRNA dysregulation in diabetic ischemic heart failure patients". Diabetes 61 (6): 1633–41. June 2012. doi:10.2337/db11-0952. PMID 22427379.
- ↑ "Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650". Biochemical and Biophysical Research Communications 406 (4): 534–8. March 2011. doi:10.1016/j.bbrc.2011.02.081. PMID 21352815. https://pubmed.ncbi.nlm.nih.gov/21352815.
Further reading
- "microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population". Clinical Microbiology and Infection 18 (8): E273-82. August 2012. doi:10.1111/j.1469-0691.2012.03849.x. PMID 22524533.
- Battista, John R, ed (2012). "Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity". PLOS ONE 7 (2): e31293. doi:10.1371/journal.pone.0031293. PMID 22347458. Bibcode: 2012PLoSO...731293G.
- "Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients". Journal of Cancer 3: 19–31. 2012. doi:10.7150/jca.3.19. PMID 22211142.
- "MicroRNA signatures differentiate melanoma subtypes". Cell Cycle 10 (11): 1845–52. June 2011. doi:10.4161/cc.10.11.15777. PMID 21543894.
- "Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway". Oncogene 30 (16): 1880–91. April 2011. doi:10.1038/onc.2010.570. PMID 21170085.
- "MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity". Biochemical and Biophysical Research Communications 395 (2): 275–80. April 2010. doi:10.1016/j.bbrc.2010.04.005. PMID 20381459.
- "Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family". Molecular Biology and Evolution 26 (5): 1179–89. May 2009. doi:10.1093/molbev/msp035. PMID 19246621.
External links
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