Biology:Mir-652 microRNA precursor family
| mir-652 | |
|---|---|
| Identifiers | |
| Symbol | mir-652 |
| Rfam | RF00872 |
| miRBase family | MIPF0000333 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-652 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, with expression levels of miRNAs and respective target mRNAs negatively correlated.
Lineage
miR-652 expression is specific to cells of the myeloid lineage, in this instance to monocytes and granulocytes.[1]
miR-652 and liver cirrhosis
miR-652 serum levels are significantly altered in alcoholic- or hepatitis-C-induced liver cirrhosis patients. They have been found to be down-regulated in the circulating monocytes of such patients, thus supporting the idea of an miR-652 role in the mediation of fibrogenic and inflammatory processes in the pathogenesis of liver cirrhosis.[2]
Expression in liver cancer
Circulating levels of miR-652 show gradual elevation with progression of liver cancer, as is also the case with miRNAs let-7a, let-7f, miR-34a, miR-98, miR-331 and miR-338.[3]
See also
References
- ↑ "Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression". PLOS ONE 7 (1): e29979. 2012. doi:10.1371/journal.pone.0029979. PMID 22276136. Bibcode: 2012PLoSO...729979A.
- ↑ "Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis". PLOS ONE 7 (3): e32999. 2012. doi:10.1371/journal.pone.0032999. PMID 22412969. Bibcode: 2012PLoSO...732999R.
- ↑ "Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages". Toxicology Letters 200 (1–2): 46–52. January 2011. doi:10.1016/j.toxlet.2010.10.013. PMID 21035526. https://pubmed.ncbi.nlm.nih.gov/21035526.
Further reading
- "Identification of Differentially Expressed MicroRNAs in Osteosarcoma". Sarcoma 2011: 732690. 2011. doi:10.1155/2011/732690. PMID 21789031.
- Uddin, Monica, ed (2011). "MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia". PLOS ONE 6 (6): e21635. doi:10.1371/journal.pone.0021635. PMID 21738743. Bibcode: 2011PLoSO...621635L.
- "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry 69 (2): 180–7. January 2011. doi:10.1016/j.biopsych.2010.09.030. PMID 21111402.
- "MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis". Journal of Cancer Research and Clinical Oncology 137 (4): 557–66. April 2011. doi:10.1007/s00432-010-0918-4. PMID 20508945.
External links
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