Biology:Mir-663 microRNA precursor family

mir-663
Identifiers
Symbol	mir-663
Rfam	RF00957
miRBase family	MIPF0000462
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Gastric cancer suppression

miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer cell lines. Its introduction into the two human gastric cancer cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation. Transfection with miR-663 also sees a resultant upregulation of cyclin B.

miR-155 upregulation and other molecular targets

Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells. Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipopolysaccharide upregulation of miR-155 by resveratrol. miR-663 also directly targets EEF1A2, translation elongation factor and well-known protooncogene.

See also

• MicroRNA

Further reading

• "MicroRNA profiling in denatured dermis of deep burn patients". Burns 38 (4): 534–40. June 2012. doi:10.1016/j.burns.2011.10.014. PMID 22360957. 
• "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology 17 (4): 346–51. May 2012. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894. 
• "MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma". Oncogene 31 (41): 4421–33. October 2012. doi:10.1038/onc.2011.629. PMID 22249270. 
• "Effect of CpG island methylation on microRNA expression in the k-562 cell line". Biochemical Genetics 50 (1–2): 122–34. February 2012. doi:10.1007/s10528-011-9478-9. PMID 22089542. 
• "Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs". Hypertension 58 (6): 1093–8. December 2011. doi:10.1161/HYPERTENSIONAHA.111.180729. PMID 22042811. 
• "Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue". Molecular Oncology 5 (6): 564–76. December 2011. doi:10.1016/j.molonc.2011.08.004. PMID 21917534. 
• "Resveratrol, MicroRNAs, Inflammation, and Cancer". Journal of Nucleic Acids 2011: 102431. 2011. doi:10.4061/2011/102431. PMID 21845215. 
• "[Expression level of miRNA-663 in different leukemic cell lines and its biological function]". Zhongguo Shi Yan Xue Ye Xue Za Zhi 19 (2): 279–83. April 2011. PMID 21518471. 
• "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology 4: 20. April 2011. doi:10.1186/1756-8722-4-20. PMID 21518431. 
• "MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells". American Journal of Physiology. Heart and Circulatory Physiology 300 (5): H1762-9. May 2011. doi:10.1152/ajpheart.00829.2010. PMID 21378144. 
• "Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution". BMC Biotechnology 11: 6. January 2011. doi:10.1186/1472-6750-11-6. PMID 21235780. 
• "MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation". Asian Pacific Journal of Cancer Prevention 12 (11): 2819–23. 2011. PMID 22393947. 
• "Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR". Biochemical and Biophysical Research Communications 403 (3–4): 357–62. December 2010. doi:10.1016/j.bbrc.2010.11.035. PMID 21078297. https://zenodo.org/record/890086. 
• "Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells". Biochemical Pharmacology 80 (12): 2057–65. December 2010. doi:10.1016/j.bcp.2010.07.003. PMID 20637737. 
• "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis 31 (9): 1561–6. September 2010. doi:10.1093/carcin/bgq143. PMID 20622002. PMC 4647642. https://hal.archives-ouvertes.fr/hal-00514095/document. 
• "MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence". Aging 2 (6): 333–43. June 2010. doi:10.18632/aging.100159. PMID 20606251. 
• Means, Terry, ed (May 2010). "Identification of unique microRNA signature associated with lupus nephritis". PLOS ONE 5 (5): e10344. doi:10.1371/journal.pone.0010344. PMID 20485490. Bibcode: 2010PLoSO...510344T. 
• "Nuclear factor TDP-43 can affect selected microRNA levels". The FEBS Journal 277 (10): 2268–81. May 2010. doi:10.1111/j.1742-4658.2010.07643.x. PMID 20423455. 
• "Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology 221 (1): 109–19. October 2009. doi:10.1002/jcp.21834. PMID 19475566. 
• "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology & Medicine 46 (2): 282–8. January 2009. doi:10.1016/j.freeradbiomed.2008.10.035. PMID 19022373. 
• "[Epigenetic inactivation of microRNA genes in mammary carcinoma]". Verhandlungen der Deutschen Gesellschaft für Pathologie 91: 214–20. 2007. PMID 18314617. 
• "Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer". The Journal of Pathology 214 (1): 17–24. January 2008. doi:10.1002/path.2251. PMID 17948228. 

External links

• Page for mir-663 microRNA precursor family at Rfam