Biology:Mir-708 microRNA precursor family
| mir-708 | |
|---|---|
| Identifiers | |
| Symbol | mir-708 |
| Rfam | RF00917 |
| miRBase family | MIPF0000397 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene.[1] It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.[2]
Ewing's Sarcoma
miR-708 has been implicated in the bone-specific Ewing's sarcoma. Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, which in turn is via repression of miR-708.[3] miR-708 targets the 3'UTR of EYA3, rather than binding directly to its promoter region. High levels of EYA3 in Ewing's sarcoma are accordingly correlated with low levels of miR-708.
miR-708 and Lung Cancer
High miR-708 expression levels are observed in lung cancers due to their oncogenic role in lung cancer tumour growth and progression. miR-708 overexpression results in increased cell proliferation, migration, and invasion, and has therefore been associated with a decreased survival rate in lung epithelial cancers. It directly downregulates the transmembrane protein 88 (TMEM88), a negative regulator of the Wnt signalling pathway.[4]
See also
References
- ↑ "Identification of novel stress-induced genes downstream of chop". The EMBO Journal 17 (13): 3619–30. July 1998. doi:10.1093/emboj/17.13.3619. PMID 9649432.
- ↑ "A CHOP-regulated microRNA controls rhodopsin expression". The Journal of Cell Biology 192 (6): 919–27. March 2011. doi:10.1083/jcb.201010055. PMID 21402790.
- ↑ "EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance". Molecular Cancer Research 10 (8): 1098–108. August 2012. doi:10.1158/1541-7786.MCR-12-0086. PMID 22723308.
- ↑ "Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers". Clinical Cancer Research 18 (13): 3658–67. July 2012. doi:10.1158/1078-0432.CCR-11-2857. PMID 22573352.
Further reading
- "Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma". Head & Neck 35 (5): 720–8. May 2013. doi:10.1002/hed.23011. PMID 22605671.
- "miRNA-708 control of CD44(+) prostate cancer-initiating cells". Cancer Research 72 (14): 3618–30. July 2012. doi:10.1158/0008-5472.CAN-12-0540. PMID 22552290.
- "MicroRNA alterations of pancreatic intraepithelial neoplasias". Clinical Cancer Research 18 (4): 981–92. February 2012. doi:10.1158/1078-0432.CCR-11-2347. PMID 22114139.
- "A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL". Human Molecular Genetics 20 (24): 4903–15. December 2011. doi:10.1093/hmg/ddr428. PMID 21926415.
- "Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs". The American Journal of Pathology 179 (4): 1851–60. October 2011. doi:10.1016/j.ajpath.2011.06.045. PMID 21854740.
- "MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells". Cancer Research 71 (19): 6208–19. October 2011. doi:10.1158/0008-5472.CAN-11-0073. PMID 21852381.
- Abdelhay, Eliana Saul Furquim Werneck, ed (April 2011). "Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer". PLOS ONE 6 (4): e18501. doi:10.1371/journal.pone.0018501. PMID 21532750.
- "MicroRNA-100 acts as a tumor suppressor in human bladder carcinoma 5637 cells". Asian Pacific Journal of Cancer Prevention 12 (11): 3001–4. 2011. PMID 22393979.
- "Differential miRNA expression profiles in bladder urothelial carcinomas". Asian Pacific Journal of Cancer Prevention 11 (4): 905–11. 2010. PMID 21133599.
- "Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers". Modern Pathology 23 (8): 1157–64. August 2010. doi:10.1038/modpathol.2010.111. PMID 20526284.
- "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets". Blood 116 (3): 437–45. July 2010. doi:10.1182/blood-2008-06-165985. PMID 20445018.
- "Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection". Cancer Research 70 (1): 36–45. January 2010. doi:10.1158/0008-5472.CAN-09-3153. PMID 20028859.
- "Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia". Leukemia 23 (2): 313–22. February 2009. doi:10.1038/leu.2008.286. PMID 18923441.
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