Biology:Mir-873 microRNA precursor family
| mir-873 | |
|---|---|
| Identifiers | |
| Symbol | mir-873 |
| Rfam | RF00910 |
| miRBase family | MIPF0000390 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-873 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Dysmaculinisation in males
Significant miR-873 reductions have been observed in the brains of dysmasculinised second generation males following the introduction of prenatal stress factors. Sexual dimorphisms in the brain are altered and there is female-like expression of key neurodevelopment genes. The common target gene for miR-873, β-glycan, has increased expression.[1] It is thought that miR-873, along with other miRNAs, may play a role in organisation of the sexually dimorphic brain due to a marked response to organisational testosterone.
Chromatin remodelling
miR-873 is associated with translational regulation of factors involved in chromatin remodelling, and is downregulated by the human T-cell leukaemia virus type 1 (HTLV-1) transactivating protein, Tax.[2] Specifically, it has been found to directly target the chromatin remodelling factors p300 and p/CAF.
See also
References
- ↑ "Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage.". J Neurosci 31 (33): 11748–55. 2011. doi:10.1523/JNEUROSCI.1887-11.2011. PMID 21849535.
- ↑ "HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter.". PLOS ONE 7 (4): e34490. 2012. doi:10.1371/journal.pone.0034490. PMID 22496815. Bibcode: 2012PLoSO...734490R.
Further reading
- Skalsky, R. L.; Cullen, B. R. (2011). Borras, Consuelo. ed. "Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene". PLOS ONE 6 (9): e24248. doi:10.1371/journal.pone.0024248. PMID 21912681. Bibcode: 2011PLoSO...624248S.
- Xu, G.; Zhang, Y.; Jia, H.; Li, J.; Liu, X.; Engelhardt, J. F.; Wang, Y. (2009). "Cloning and identification of microRNAs in bovine alveolar macrophages". Molecular and Cellular Biochemistry 332 (1–2): 9–16. doi:10.1007/s11010-009-0168-4. PMID 19507003.
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