Biology:NDC80
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.[1][2][3]
Function
Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25,[4] and SPC24. This protein complex has microtubule-binding domains.[5]
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[3]
Interactions
NDC80 has been shown to interact with MIS12,[6][7] NEK2[8][9] and PSMC2.[9]
References
- ↑ "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis". Molecular and Cellular Biology 17 (10): 6049–56. October 1997. doi:10.1128/mcb.17.10.6049. PMID 9315664.
- ↑ "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science 297 (5590): 2267–70. September 2002. doi:10.1126/science.1075596. PMID 12351790. Bibcode: 2002Sci...297.2267M.
- ↑ 3.0 3.1 "Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10403.
- ↑ Human kinetochore protein Spc25 Q9HBM1
- ↑ "Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes". The Journal of Cell Biology 216 (2): 379–391. February 2017. doi:10.1083/jcb.201608043. PMID 28034897.
- ↑ "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development 18 (18): 2255–68. September 2004. doi:10.1101/gad.1234104. PMID 15371340.
- ↑ "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology 6 (11): 1135–41. November 2004. doi:10.1038/ncb1187. PMID 15502821.
- ↑ "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". The Journal of Biological Chemistry 277 (51): 49408–16. December 2002. doi:10.1074/jbc.M207069200. PMID 12386167.
- ↑ 9.0 9.1 "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". The Journal of Biological Chemistry 272 (38): 24081–7. September 1997. doi:10.1074/jbc.272.38.24081. PMID 9295362.
Further reading
- "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". The Journal of Biological Chemistry 272 (38): 24081–7. September 1997. doi:10.1074/jbc.272.38.24081. PMID 9295362.
- "Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins". Molecular and Cellular Biology 19 (8): 5417–28. August 1999. doi:10.1128/mcb.19.8.5417. PMID 10409732.
- "Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p". Molecular and Cellular Biology 20 (10): 3529–37. May 2000. doi:10.1128/MCB.20.10.3529-3537.2000. PMID 10779342.
- "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". The Journal of Biological Chemistry 277 (51): 49408–16. December 2002. doi:10.1074/jbc.M207069200. PMID 12386167.
- "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". Molecular & Cellular Proteomics 3 (1): 93–104. January 2004. doi:10.1074/mcp.M300072-MCP200. PMID 14602875.
- "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores". Current Biology 13 (23): 2103–9. December 2003. doi:10.1016/j.cub.2003.10.056. PMID 14654001.
- "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry 279 (13): 13076–85. March 2004. doi:10.1074/jbc.M310224200. PMID 14699129.
- "NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling". The Journal of Biological Chemistry 279 (19): 20049–57. May 2004. doi:10.1074/jbc.M314205200. PMID 14978040.
- "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo". Current Biology 14 (7): 611–7. April 2004. doi:10.1016/j.cub.2004.03.031. PMID 15062103.
- "Sgt1 is required for human kinetochore assembly". EMBO Reports 5 (6): 626–31. June 2004. doi:10.1038/sj.embor.7400154. PMID 15133482.
- "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1". Chromosoma 113 (1): 1–15. August 2004. doi:10.1007/s00412-004-0288-2. PMID 15235793.
- "Timing and checkpoints in the regulation of mitotic progression". Developmental Cell 7 (1): 45–60. July 2004. doi:10.1016/j.devcel.2004.06.006. PMID 15239953.
- "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development 18 (18): 2255–68. September 2004. doi:10.1101/gad.1234104. PMID 15371340.
- "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology 6 (11): 1135–41. November 2004. doi:10.1038/ncb1187. PMID 15502821.
- "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". The Journal of Biological Chemistry 280 (3): 2092–104. January 2005. doi:10.1074/jbc.M403080200. PMID 15504738.
- "Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites". Molecular Biology of the Cell 16 (2): 519–31. February 2005. doi:10.1091/mbc.E04-09-0852. PMID 15548592.
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