Biology:NDFIP2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.[1][2][3]
Interactions
NDFIP2 has been shown to interact with NEDD4.[4]
Conversely, it has also been shown that NDFIP2 does not interact with the NEDD4-2 variant in neurons of the dorsal root ganglia, but it does participate in the regulation of TRKA, TRKB, and TRKC. This could indicate a direct relationship between NDFIP2 and the cellular mechanisms of nociception.[5]
References
- ↑ "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res 6 (5): 329–36. Jan 2000. doi:10.1093/dnares/6.5.329. PMID 10574461.
- ↑ "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem 277 (33): 29406–16. Aug 2002. doi:10.1074/jbc.M203018200. PMID 12050153.
- ↑ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54602.
- ↑ Cristillo, Anthony D; Nie Linghu; Macri Mirtha J; Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. ISSN 0021-9258. PMID 12796489.
- ↑ Cañada-García, Daniel; Hernández-García, Ana; Vicente-García, Cristina; Valero, Jorge; Ayon-Olivas, Maurilyn; Kumar, Sharad; Sendtner, Michael; Arévalo, Juan Carlos (2026-03-31). "Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels" (in en). Cell Death & Disease. doi:10.1038/s41419-026-08670-9. ISSN 2041-4889. https://www.nature.com/articles/s41419-026-08670-9.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. 2003. doi:10.1038/sj.onc.1206406. PMID 12761501.
- "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes.". J. Biol. Chem. 278 (36): 34587–97. 2003. doi:10.1074/jbc.M304723200. PMID 12796489.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.". J. Cell Sci. 117 (Pt 16): 3679–89. 2005. doi:10.1242/jcs.01212. PMID 15252135.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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