Biology:NEAT1
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Nuclear Enriched Abundant Transcript 1 (NEAT1) is a ~3.2 kb novel nuclear long non-coding RNA (RIKEN cDNA 2310043N10Rik). It is also known as Virus Inducible NonCoding RNA (VINC) or MEN epsilon RNA. It is transcribed from the multiple endocrine neoplasia locus.[1][2][3][4]
Expression of NEAT1 is induced in mouse brains during infection by Japanese encephalitis virus and rabies virus. NEAT1 is constitutively expressed in a number of non-neuronal tissues and cell lines.
NEAT1 localizes to specific nuclear structures called paraspeckles.[5][6][7] NEAT1 RNA interacts with a paraspeckle protein known as P54nrb or NONO and it is essential for paraspeckle formation. Some studies demonstrate that NEAT1 RNA is essential for the formation and maintenance of paraspeckles. Thus, this novel noncoding RNA appears to have an important structural role in the nuclear paraspeckles.[5][6][7] There are two isoforms of NEAT1, NEAT1_1 and NEAT1_2, which are regulated by alternative 3′-end processing.[8] Mutant mice lacking Neat1 do not exhibit overt external abnormalities, but the female mice exhibit decreased fertility and lactation defect.[9][10]
See also
References
- ↑ "Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses.". J Gen Virol 84 (Pt 7): 1729–1735. 2003. doi:10.1099/vir.0.18826-0. PMID 12810866.
- ↑ "Identification and characterization of a virus-inducible non-coding RNA in mouse brain.". J Gen Virol 87 (Pt 7): 1991–1995. 2006. doi:10.1099/vir.0.81768-0. PMID 16760401.
- ↑ "A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.". BMC Genomics 8: 39. 2007. doi:10.1186/1471-2164-8-39. PMID 17270048.
- ↑ "Entrez Gene: nuclear paraspeckle assembly transcript 1 (non-protein coding)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=283131.
- ↑ 5.0 5.1 "MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.". Proc Natl Acad Sci U S A 106 (8): 2525–2530. 2009. doi:10.1073/pnas.0807899106. PMID 19188602.
- ↑ 6.0 6.1 "An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.". Mol Cell 33 (6): 717–726. 2009. doi:10.1016/j.molcel.2009.01.026. PMID 19217333.
- ↑ 7.0 7.1 "MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.". Genome Res 19 (3): 347–359. 2009. doi:10.1101/gr.087775.108. PMID 19106332.
- ↑ "Alternative 3′-end Processing of Long Noncoding RNA Initiates Construction of Nuclear Paraspeckles.". EMBO J 31 (20): 4020–4034. 2012. doi:10.1038/emboj.2012.251. PMID 3474925.
- ↑ "The lncRNA Neat1 Is Required for Corpus Luteum Formation and the Establishment of Pregnancy in a Subpopulation of Mice.". Development 141 (23): 4618–4627. 2014. doi:10.1242/dev.110544. PMID 25359727.
- ↑ "The Long Noncoding RNA Neat1 Is Required for Mammary Gland Development and Lactation.". RNA 20 (12): 1844–1849. 2014. doi:10.1261/rna.047332.114. PMID 25316907.
Further reading
- "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.". Genome Res. 7 (7): 725–735. 1997. doi:10.1101/gr.7.7.725. PMID 9253601.
- "Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.". Nat. Cell Biol. 13 (1): 95–101. 2011. doi:10.1038/ncb2140. PMID 21170033.
- Peyman JA (2001). "Mammalian expression cloning of two human trophoblast suppressors of major histocompatibility complex genes.". Am. J. Reprod. Immunol. 45 (6): 382–392. doi:10.1111/j.8755-8920.2001.450603.x. PMID 11458881.
- "Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes.". Biochem. Biophys. Res. Commun. 301 (3): 718–724. 2003. doi:10.1016/S0006-291X(03)00028-7. PMID 12565840.
- "Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.". Mol. Cell 35 (4): 467–478. 2009. doi:10.1016/j.molcel.2009.06.027. PMID 19716791.
- Peyman JA (1999). "Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid.". Biol. Reprod. 60 (1): 23–31. doi:10.1095/biolreprod60.1.23. PMID 9858482.
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