Biology:NLRP6
From HandWiki
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[1]
References
- ↑ "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. October 2002. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. Bibcode: 2002FEBSL.530...73G.
Further reading
- "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. 2010. doi:10.1038/gene.2010.1. PMID 20237496.
- "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. 2003. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. Bibcode: 2003FEBSL.538..173A.
- "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. 2003. doi:10.1038/nrm1019. PMID 12563287.
- "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. 2002. doi:10.1074/jbc.M203915200. PMID 12019269.
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