Biology:NME1
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Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene.[1] It is thought to be a metastasis suppressor.
Function
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[2]
Interactions
NME1 has been shown to interact with:
- Aurora A kinase,[3]
- CD29[4]
- NME3,[5][6]
- Protein SET,[7]
- RAR-related orphan receptor alpha,[8]
- RAR-related orphan receptor beta,[8] and
- TERF1.[9]
See also
References
- ↑ "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. February 1994. doi:10.1007/bf00218915. PMID 8270257.
- ↑ "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4830.
- ↑ "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465–75. December 2002. doi:10.1093/nar/gkf678. PMID 12490715.
- ↑ "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. June 2002. doi:10.1074/jbc.M200200200. PMID 11919189.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. September 2000. doi:10.1038/sj.cdd.4400720. PMID 11042679.
- ↑ "SET-ting the stage for life and death". Cell 112 (5): 589–91. March 2003. doi:10.1016/s0092-8674(03)00151-x. PMID 12628178.
- ↑ 8.0 8.1 "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. October 1996. doi:10.1006/bbrc.1996.1471. PMID 8858107.
- ↑ "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. February 1998. doi:10.1006/bbrc.1997.8097. PMID 9480811.
Further reading
- "Nm23 and tumour metastasis: basic and translational advances". Biochem. Soc. Symp. 63: 261–71. 1998. PMID 9513729.
- "Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis". Clin. Exp. Metastasis 19 (6): 465–76. 2002. doi:10.1023/A:1020396722860. PMID 12405283.
- "Nm23-H1: a metastasis-associated gene". Taiwan J Obstet Gynecol 45 (2): 107–13. 2006. doi:10.1016/S1028-4559(09)60206-0. PMID 17197349.
- "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. 1991. doi:10.1016/S0021-9258(18)31515-1. PMID 1851158.
- "Somatic allelic deletion of nm23 in human cancer". Cancer Res. 51 (9): 2490–3. 1991. PMID 2015608.
- "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification". J. Clin. Invest. 88 (1): 341–5. 1991. doi:10.1172/JCI115299. PMID 2056128.
- "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature 342 (6246): 177–80. 1989. doi:10.1038/342177a0. PMID 2509941. Bibcode: 1989Natur.342..177R.
- "Mutation in the nm23 gene is associated with metastasis in colorectal cancer". Cancer Res. 53 (4): 717–20. 1993. PMID 7916650.
- "Nm23-H1 mutation in neuroblastoma". Nature 370 (6488): 335–6. 1994. doi:10.1038/370335a0. PMID 8047138. Bibcode: 1994Natur.370..335C. https://deepblue.lib.umich.edu/bitstream/2027.42/62612/1/370335a0.pdf.
- "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. 1993. doi:10.1016/S0021-9258(19)74458-5. PMID 8245015.
- "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science 261 (5120): 478–80. 1993. doi:10.1126/science.8392752. PMID 8392752. Bibcode: 1993Sci...261..478P.
- "Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect". Hum. Mol. Genet. 2 (7): 857–62. 1993. doi:10.1093/hmg/2.7.857. PMID 8395939. https://pdfs.semanticscholar.org/02da/eaa5c65a73f57ca8dc313ac8bb8408b011fa.pdf.
- "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells". J. Biol. Chem. 271 (41): 25107–16. 1996. doi:10.1074/jbc.271.41.25107. PMID 8810265.
- "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. 1996. doi:10.1006/bbrc.1996.1471. PMID 8858107.
- "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. 1998. doi:10.1006/bbrc.1997.8097. PMID 9480811.
- "Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis". J. Biol. Chem. 273 (10): 5662–9. 1998. doi:10.1074/jbc.273.10.5662. PMID 9488696.
- "Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation". J. Biol. Chem. 273 (22): 13663–8. 1998. doi:10.1074/jbc.273.22.13663. PMID 9593706.
- "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics 61 (1): 5–14. 1999. doi:10.1006/geno.1999.5939. PMID 10512675.
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