Biology:NME2
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Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.[1][2]
Function
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.[2]
Interactions
NME2 has been shown to interact with NME3[3][4] and HERC5.[5]
References
- ↑ "Identification of a second human nm23 gene, nm23-H2". Cancer Res. 51 (1): 445–9. February 1991. PMID 1988104.
- ↑ 2.0 2.1 "Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4831.
- ↑ "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. September 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- ↑ "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. September 2000. doi:10.1038/sj.cdd.4400720. PMID 11042679.
- ↑ "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13): 2105–17. July 2008. doi:10.1007/s00018-008-8148-5. PMID 18535780.
Further reading
- "Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression". Nucleic Acids Res. 37 (1): 172–83. 2009. doi:10.1093/nar/gkn919. PMID 19033359.
- "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. 1991. doi:10.1016/S0021-9258(18)31515-1. PMID 1851158.
- "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature 342 (6246): 177–80. 1989. doi:10.1038/342177a0. PMID 2509941. Bibcode: 1989Natur.342..177R.
- "The crystal structure of a human nucleoside diphosphate kinase, NM23-H2". J. Mol. Biol. 251 (4): 574–87. 1995. doi:10.1006/jmbi.1995.0457. PMID 7658474.
- "The human NME2 gene lies within 18kb of NME1 in chromosome 17". Genes Chromosomes Cancer 6 (4): 245–8. 1993. doi:10.1002/gcc.2870060411. PMID 7685630.
- "The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma". J. Biol. Chem. 270 (22): 13392–8. 1995. doi:10.1074/jbc.270.22.13392. PMID 7768941.
- "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. 1993. doi:10.1016/S0021-9258(19)74458-5. PMID 8245015.
- "Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2". Oncogene 8 (2): 497–502. 1993. PMID 8381224.
- "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science 261 (5120): 478–80. 1993. doi:10.1126/science.8392752. PMID 8392752. Bibcode: 1993Sci...261..478P.
- "Localization of a second NM23 gene, NME2, to chromosome 17q21-q22". Genomics 17 (2): 522–4. 1993. doi:10.1006/geno.1993.1362. PMID 8406509.
- "A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase". Eur. J. Biochem. 234 (1): 200–7. 1995. doi:10.1111/j.1432-1033.1995.200_c.x. PMID 8529641.
- "The nucleoside diphosphate kinase of human neutrophils". Biochem. J. 316 ( Pt 1) (1): 233–8. 1996. doi:10.1042/bj3160233. PMID 8645210.
- "X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution". Structure 3 (12): 1307–14. 1995. doi:10.1016/S0969-2126(01)00268-4. PMID 8747457.
- "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. 1996. doi:10.1006/bbrc.1996.1471. PMID 8858107.
- "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. 1998. doi:10.1006/bbrc.1997.8097. PMID 9480811.
- "Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit". Exp. Cell Res. 246 (2): 355–67. 1999. doi:10.1006/excr.1998.4318. PMID 9925751.
- "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. 2000. doi:10.1038/sj.cdd.4400720. PMID 11042679.
- "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma". Exp. Cell Res. 261 (1): 127–38. 2000. doi:10.1006/excr.2000.5037. PMID 11082283.
- "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I". J. Biol. Chem. 277 (21): 18961–6. 2002. doi:10.1074/jbc.M108818200. PMID 11872741.
- "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. 2002. doi:10.1074/jbc.M200200200. PMID 11919189.
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