Biology:NOS1AP
 Generic protein structure example |
Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.[1][2][3]
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.[3] NOS1AP polymorphisms has been associated with the QT interval length.[4]
Interactions
NOS1AP has been shown to interact with:
References
- ↑ "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. February 1998. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ↑ 2.0 2.1 "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95". Neuron 20 (1): 115–24. Mar 1998. doi:10.1016/S0896-6273(00)80439-0. PMID 9459447.
- ↑ 3.0 3.1 "Entrez Gene: NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9722.
- ↑ "A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization". Nat. Genet. 38 (6): 644–51. 2006. doi:10.1038/ng1790. PMID 16648850.
- ↑ 5.0 5.1 "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. August 2000. doi:10.1074/jbc.M000955200. PMID 10827173.
- ↑ "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron 28 (1): 183–93. October 2000. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993.
- ↑ "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. March 2002. doi:10.1073/pnas.261705799. PMID 11867766. Bibcode: 2002PNAS...99.3199J.
Further reading
- "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. 2000. doi:10.1074/jbc.M000955200. PMID 10827173.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population". Biochem. Biophys. Res. Commun. 328 (4): 809–15. 2005. doi:10.1016/j.bbrc.2005.01.037. PMID 15707951.
- "Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder". PLOS Med. 2 (10): e263. 2005. doi:10.1371/journal.pmed.0020263. PMID 16146415.
- "Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample". Biol. Psychiatry 59 (2): 195–7. 2006. doi:10.1016/j.biopsych.2005.08.015. PMID 16202394.
- "Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish". Hum. Hered. 64 (4): 214–9. 2007. doi:10.1159/000103630. PMID 17565224.
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