Biology:NUBP2
![]() Generic protein structure example |
ParA/MinD ATPase like | |||||||||
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Identifiers | |||||||||
Symbol | ParA | ||||||||
Pfam | PF10609 | ||||||||
InterPro | IPR019591 | ||||||||
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Nucleotide-binding protein 2 (NBP 2) also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2 gene.[1]
NUBP2 is a member of the NUBP/MRP gene subfamily of ATP-binding proteins.[2] There are two types in eukaryotes NUBP1 and NUBP2, and one novel human gene that define NBP nucleotide-binding proteins (NUBP/MRP-multidrug resistance-associated protein)[1] in mammalian cells requires the maturation of cytosolic[3] iron-sulfur (Fe/S)[4] proteins as Nubp1 is involved in the formation of extramitochondrial Fe/S proteins[2] the cell division inhibitor MinD is homologous[5] and involve two proteins components of the (FeS) protein assembly machinery closely similar cytosolic[2] soluble[4] P loop[5] NTPase where Nar1[6][7] is required for assembly,[8] identified Cfd1p[9][10] in cytosolic and nuclear Fe/S protein biogenesis[4] in yeast.[11] Nubp proteins NTPase Nbp35p.[7][8] MinD is homologous to members in MinD of E. coli, a relative of the ParA family.[5][12][13]
Morphology
Further information: Morphology
NBP35 bacterial plasmids F (the classical Escherichia coli sex factor)[5] is found in all nuclear genes in vegetative and gametic flagella of the unicellular green algae C. reinhardtii and nuclear Fe/S protein biogenesis required for cytosolic iron-sulfur protein assembly; MNP =MRP-like; MRP (Multiple Resistance and pH adaptation) MRP/NBP35-like P-loop NTPase similar to; and functions as minD_arch; cell division ATPase MinD, archaeal and homologue's of NUBP1. The NBP35 gene is conserved in archaea[14] Bacteria, Metazoa, Fungi and other Eukaryotes and with considerable divergence from the yeast; Cfd1-Nbp35 Fe-S to man. In a scaffold complex[15] protein to form large molecular assemblies that store Fe(III) and 4Fe-4S seen as secondary to defects inactivated to accomplish its functions as physiologically relevant form(s) Fe/S proteins Iron regulatory protein 1 (IRP1) is regulated through[10] prevents deficiencies and increased mutation rates[13] that characterized a plant P loop NTPase with sequence similarity to Nbp35 homologue's of NUBP1.[16]
Interactions
NUBP2 has been shown to interact with...
- ACO1 Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1)[10][17]
- MAPK8IP3 C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3)[18]
- IGFALS Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS)[18][19]
- KIF11 Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5)[20]
- SEPP1 Selenoprotein P precursor (SeP)[13]
- CA1 Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonic anhydrase I) (Carbonate dehydratase I) (CA-I)[12][13][16]
References
- ↑ 1.0 1.1 "Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes.". Genomics 60 (2): 152–60. 1999. doi:10.1006/geno.1999.5898. PMID 10486206.
- ↑ 2.0 2.1 2.2 "Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.". Mol. Cell. Biol. 28 (17): 5517–28. 2008. doi:10.1128/MCB.00545-08. PMID 18573874.
- ↑ "The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol.". Nat Chem Biol 3 (5): 278–86. 2007. doi:10.1038/nchembio872. PMID 17401378.
- ↑ 4.0 4.1 4.2 "The eukaryotic P-loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery.". Proc Natl Acad Sci U S A 102 (9): 3266–71. 2005. doi:10.1073/pnas.0406447102. PMID 15728363. Bibcode: 2005PNAS..102.3266H.
- ↑ 5.0 5.1 5.2 5.3 "A family of ATPases involved in active partitioning of diverse bacterial plasmids.". Mol. Microbiol. 4 (9): 1455–63. 1990. doi:10.1111/j.1365-2958.1990.tb02056.x. PMID 2149583.
- ↑ "The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.". Mol Cell Biol 25 (24): 10833–41. 2005. doi:10.1128/MCB.25.24.10833-10841.2005. PMID 16314508.
- ↑ 7.0 7.1 "Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.". J Biol Chem 280 (11): 10135–40. 2005. doi:10.1074/jbc.M413731200. PMID 15649888. http://db.yeastgenome.org/cgi-bin/reference/reference.pl?pubmed=15649888.
- ↑ 8.0 8.1 "Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis.". Biochem Soc Trans 33 (Pt.1): 86–9. 2005. doi:10.1042/BST0330086. PMID 15667273. http://db.yeastgenome.org/cgi-bin/reference/reference.pl?pubmed=15667273.
- ↑ "Functional link between ribosome formation and biogenesis of iron-sulfur proteins.". EMBO J. 24 (3): 580–8. 2005. doi:10.1038/sj.emboj.7600540. PMID 15660135.
- ↑ 10.0 10.1 10.2 "A novel eukaryotic factor for cytosolic Fe-S cluster assembly.". EMBO J. 22 (18): 4826–35. 2003. doi:10.1093/emboj/cdg455. PMID 12970194.
- ↑ "Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins.". Mol Biol Rep 37 (3): 1165–8. 2010. doi:10.1007/s11033-009-9477-7. PMID 19263241.
- ↑ 12.0 12.1 "The bacterial ParA-ParB partitioning proteins.". J Biotechnol 91 (2): 1–34. 2001. doi:10.1016/S0168-1656(01)00293-0. ISSN 0168-1656. PMID 11522360.
- ↑ 13.0 13.1 13.2 13.3 "Non-pathogenic bacteria modulate colonic epithelial gene expression in germ-free mice.". Scand J Gastroenterol 38 (6): 626–34. 2003. doi:10.1080/00365510310000376. ISSN 0036-5521. PMID 12825871.
- ↑ "Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe-2S] and [4Fe-4S] clusters in two distinct domains.". Biochem Biophys Res Commun 378 (4): 810–5. 2009. doi:10.1016/j.bbrc.2008.11.138. PMID 19084504.
- ↑ "The essential cytosolic iron-sulfur protein Nbp35 acts without Cfd1 partner in the green lineage.". J Biol Chem 283 (51): 35797–804. 2008. doi:10.1074/jbc.M807303200. PMID 18957412.
- ↑ 16.0 16.1 "Entrez Gene: UniGene Hs.256549 Nucleotide binding protein 2 (MinD homolog, E. coli) (NUBP2)". https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=256549.
- ↑ "Entrez Gene: NUCLEOTIDE-BINDING PROTEIN 2; NUBP2 CYTOSOLIC FE-S CLUSTER DEFICIENT 1, S. CEREVISIAE, HOMOLOG OF; CFD1 Gene map locus: 16p13.3". https://www.ncbi.nlm.nih.gov/omim?term=610779.
- ↑ 18.0 18.1 "Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA.". Genome Res. 10 (7): 916–23. 2000. doi:10.1101/gr.10.7.916. PMID 10899141.
- ↑ "Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA.". Genome Res. 11 (11): 1833–41. 2001. doi:10.1101/gr.194301. PMID 11691847.
- ↑ "Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.". J Cell Sci 119 (Pt 10): 2035–47. 2006. doi:10.1242/jcs.02922. PMID 16638812.
Further reading
- "Genetic susceptibility to distinct bladder cancer subphenotypes.". Eur. Urol. 57 (2): 283–92. 2010. doi:10.1016/j.eururo.2009.08.001. PMID 19692168.
- "A novel eukaryotic factor for cytosolic Fe-S cluster assembly.". EMBO J. 22 (18): 4826–35. 2003. doi:10.1093/emboj/cdg455. PMID 12970194.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.". Environ. Mol. Mutagen. 50 (4): 285–90. 2009. doi:10.1002/em.20452. PMID 19170196.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "PTEN identified as important risk factor of chronic obstructive pulmonary disease.". Respir Med 103 (12): 1866–70. 2009. doi:10.1016/j.rmed.2009.06.016. PMID 19625176.
- "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.". Carcinogenesis 29 (10): 1938–43. 2008. doi:10.1093/carcin/bgn178. PMID 18676680.