Biology:Naive B cell
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils, spleen, and primary lymphoid follicles in lymph nodes.
Once exposed to an antigen, the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. Plasma cells do not last long in the circulation; this is in contrast to memory cells that last for very long periods of time. Memory cells do not secrete antibodies until activated by their specific antigen. [1][2]
Naive B cells play a key role in predicting humoral responses to COVID-19 mRNA vaccines in immunocompromised patients, specifically measuring naive B cell levels could help predict and improve vaccination outcomes.[3]
Notes and references
- ↑ "Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes". Clin. Cancer Res. 10 (1 Pt 1): 144–54. January 2004. doi:10.1158/1078-0432.CCR-1026-3. PMID 14734463. http://clincancerres.aacrjournals.org/content/10/1/144.full.
- ↑ Lang ML (Aug 2009). "How do natural killer T cells help B cells?". Expert Rev Vaccines 8 (8): 1109–21. doi:10.1586/erv.09.56. PMID 19627191.
- ↑ Schulz, Eduard; Hodl, Isabel; Forstner, Patrick; Hatzl, Stefan; Sareban, Nazanin; Moritz, Martina; Fessler, Johannes; Dreo, Barbara et al. (2021-12-07). "CD19+IgD+CD27- Naïve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients". Frontiers in Immunology 12. doi:10.3389/fimmu.2021.803742. ISSN 1664-3224. PMID 34950155.
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