Biology:Nkx2-2as
From HandWiki
| NK2 transcription factor related, locus 2 (Drosophila), antisense | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | Nkx2-2as |
| Entrez | 100313531 |
| RefSeq (mRNA) | NR_030769 |
| Other data | |
| Chromosome | 2: 146.99 - 147.18 Mb |
Nkx2-2as (Nkx2-2 antisense) is a long non-coding RNA. It is located in the cytoplasm of the cell. Nkx2-2as is involved in Neural development. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox gene Nkx2-2 and enhances induction of the differentiation of oligodendrocytes.[1][2][3][4] Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.[1][2]
See also
References
- ↑ 1.0 1.1 "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications 372 (4): 691–6. August 2008. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
- ↑ 2.0 2.1 "Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System". Therapeutic Ribonucleic Acids in Brain Tumors. Berlin, Heidelberg: Springer. 2009. pp. 453–470. doi:10.1007/978-3-642-00475-9_20. ISBN 978-3-642-00474-2. https://archive.org/details/therapeuticribon00erdm.
- ↑ "Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation". BMC Neuroscience 11: 14. February 2010. doi:10.1186/1471-2202-11-14. PMID 20137068.
- ↑ "Long non-coding RNAs in nervous system function and disease". Brain Research 1338: 20–35. June 2010. doi:10.1016/j.brainres.2010.03.110. PMID 20380817.
Further reading
- "The genetic signatures of noncoding RNAs". PLOS Genetics 5 (4): e1000459. April 2009. doi:10.1371/journal.pgen.1000459. PMID 19390609.
External links
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