Biology:Outer membrane efflux proteins

From HandWiki

Proteins in the outer membrane efflux protein family form trimeric (three-piece) channels that allow export of a variety of substrates in gram-negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12-stranded beta-barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

References

  • "Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps". Journal of Molecular Biology 287 (3): 695–715. April 1999. doi:10.1006/jmbi.1999.2630. PMID 10092468.