Biology:PCDH8
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[1][2][3]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[3]
References
- ↑ "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics 53 (1): 81–9. Dec 1998. doi:10.1006/geno.1998.5467. PMID 9787079.
- ↑ "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol 17 (10): 6157–66. Oct 1997. doi:10.1128/MCB.17.10.6157. PMID 9315676.
- ↑ 3.0 3.1 "Entrez Gene: PCDH8 protocadherin 8". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5100.
Further reading
- "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. 2000. doi:10.1101/gad.14.10.1169. PMID 10817752.
- "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. 2000. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. 1999. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
- "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation". J. Biol. Chem. 274 (27): 19473–1979. 1999. doi:10.1074/jbc.274.27.19473. PMID 10383464.
- "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. 2000. doi:10.1073/pnas.060027397. PMID 10716726.
- "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. 2001. doi:10.1101/gr.167301. PMID 11230163.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Screening the human protocadherin 8 (PCDH8) gene in schizophrenia". Genes, Brain and Behavior 1 (3): 187–91. 2003. doi:10.1034/j.1601-183X.2002.10307.x. PMID 12884975.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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