Biology:PCP4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.[1][2][3] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).[4] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.[4][5]
Function
PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.[4] PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).[4][6][7]
References
- ↑ "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet 98 (6): 672–7. Jan 1997. doi:10.1007/s004390050282. PMID 8931698.
- ↑ "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet 22 (3): 167–75. Dec 1996. doi:10.1007/BF02369907. PMID 8914602.
- ↑ "Entrez Gene: PCP4 Purkinje cell protein 4". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5121.
- ↑ 4.0 4.1 4.2 4.3 "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. 2011. doi:10.1128/MCB.05208-11. PMID 21576365.
- ↑ "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. 1989. doi:10.1073/pnas.86.14.5651. PMID 2748608. Bibcode: 1989PNAS...86.5651S.
- ↑ "A new role for IQ motif proteins in regulating calmodulin function.". J. Biol. Chem. 278 (50): 49667–70. 2004. doi:10.1074/jbc.C300372200. PMID 14551202.
- ↑ "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. 2009. doi:10.1074/jbc.M808067200. PMID 19106096.
Further reading
- "PCP4 maps between D21S345 and P31P10SP6 on chromosome 21q22.2→q22.3.". Cytogenet. Cell Genet. 78 (1): 44–5. 1997. doi:10.1159/000134623. PMID 9345904.
- "PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease.". Neuroscience 86 (4): 1055–63. 1998. doi:10.1016/S0306-4522(98)00130-4. PMID 9697113.
- "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7. 2006. doi:10.1186/1471-2164-7-155. PMID 16780588.
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