Biology:PCTK1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene.[1][2]
Function
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.[2]
Interactions
PCTK1 has been shown to interact with CDK5R1.[3]
References
- ↑ "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene 7 (11): 2249–58. Dec 1992. PMID 1437147.
- ↑ 2.0 2.1 "Entrez Gene: PCTK1 PCTAIRE protein kinase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5127.
- ↑ "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. Aug 2002. doi:10.1074/jbc.M201161200. PMID 12084709.
Further reading
- "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. 1992. doi:10.1002/j.1460-2075.1992.tb05360.x. PMID 1639063.
- "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3". Cytogenet. Cell Genet. 71 (2): 155–7. 1995. doi:10.1159/000134097. PMID 7656587.
- "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics 21 (1): 217–21. 1994. doi:10.1006/geno.1994.1245. PMID 8088790.
- "X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse". Hum. Mol. Genet. 5 (3): 391–401. 1996. doi:10.1093/hmg/5.3.391. PMID 8852665.
- "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins". Mol. Gen. Genet. 254 (5): 571–7. 1997. doi:10.1007/s004380050453. PMID 9197417.
- "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E". Genomics 43 (2): 183–90. 1997. doi:10.1006/geno.1997.4797. PMID 9244435.
- "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. 1998. doi:10.1074/jbc.273.39.25388. PMID 9738006.
- "Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins". Eur. J. Biochem. 257 (1): 112–20. 1998. doi:10.1046/j.1432-1327.1998.2570112.x. PMID 9799109.
- "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation". Cell Growth Differ. 10 (3): 173–81. 1999. PMID 10099831.
- "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. 2002. doi:10.1074/jbc.M201161200. PMID 12084709.
- "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells". J. Cell Sci. 115 (Pt 17): 3479–90. 2002. doi:10.1242/jcs.115.17.3479. PMID 12154078. http://repository.ust.hk/ir/bitstream/1783.1-1608/1/3479.pdf.
- "Protein profile of tax-associated complexes". J. Biol. Chem. 279 (1): 495–508. 2004. doi:10.1074/jbc.M310069200. PMID 14530271.
- "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. 2005. doi:10.1242/jcs.02496. PMID 16091426.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis". J. Biol. Chem. 281 (15): 9852–8. 2006. doi:10.1074/jbc.M513496200. PMID 16461345.
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