Biology:PDE6C

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.

Further reading

• Deloukas P; Earthrowl ME; Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–381. doi:10.1038/nature02462. PMID 15164054. Bibcode: 2004Natur.429..375D. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Bertazolli-Filho R; Ghosh S; Huang W et al. (2001). "Molecular evidence that human ocular ciliary epithelium expresses components involved in phototransduction". Biochem. Biophys. Res. Commun. 284 (2): 317–325. doi:10.1006/bbrc.2001.4970. PMID 11394879. 
• Harrington JJ; Sherf B; Rundlett S et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• Gao YQ; Danciger M; Longmuir R et al. (1999). "Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations". Invest. Ophthalmol. Vis. Sci. 40 (8): 1818–1822. PMID 10393054. 
• Feshchenko EA; Andreeva SG; Suslova VA et al. (1996). "Human cone-specific cGMP phosphodiesterase alpha' subunit: complete cDNA sequence and gene arrangement". FEBS Lett. 381 (1–2): 149–152. doi:10.1016/0014-5793(96)00104-4. PMID 8641425. 
• "Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase". Gene 166 (2): 205–211. 1996. doi:10.1016/0378-1119(95)00585-4. PMID 8543163. 
• Piriev NI; Viczian AS; Ye J et al. (1996). "Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24". Genomics 28 (3): 429–435. doi:10.1006/geno.1995.1171. PMID 7490077. 

External links

• GeneReviews/NIH/NCBI/UW entry on Achromatopsia
• OMIM entries on Achromatopsia