Biology:PDE8A
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[3]
References
- ↑ "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun 246 (3): 570–577. Jul 1998. doi:10.1006/bbrc.1998.8684. PMID 9618252.
- ↑ "Entrez Gene: PDE8A phosphodiesterase 8A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151.
- ↑ "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology 420 (1): 32–42. Sep 2011. doi:10.1016/j.virol.2011.08.013. PMID 21920574.
Further reading
- Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA.". Annu. Rev. Biochem. 71: 817–846. doi:10.1146/annurev.biochem.71.110601.135501. PMID 12045112.
- "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–491. 2001. doi:10.1096/fj.00-0354com. PMID 11156964.
- "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–6324. 2001. doi:10.1073/pnas.101131098. PMID 11371644. Bibcode: 2001PNAS...98.6319G.
- "Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution.". Gene 280 (1–2): 183–194. 2002. doi:10.1016/S0378-1119(01)00783-1. PMID 11738832.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–574. 2003. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (51): 17634–17639. 2005. doi:10.1073/pnas.0407649101. PMID 15596729.
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