Biology:PELO
 Generic protein structure example |
Protein pelota homolog is a protein that in humans is encoded by the PELO gene.[1][2]
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.[2] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.[3] It is a paralog of the release factor eRF1.
The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.[4] Human, yeast (Dom34), plant, and worm homologs are reported in 1995,[5] followed by one found in archaea.[6]
References
- ↑ "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics 90 (1–2): 75–8. Nov 2000. doi:10.1159/000015667. PMID 11060452.
- ↑ 2.0 2.1 "Entrez Gene: PELO pelota homolog (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53918.
- ↑ "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal 33 (3): 265–76. February 2014. doi:10.1002/embj.201386123. PMID 24424461.
- ↑ "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics 135 (2): 489–505. October 1993. doi:10.1093/genetics/135.2.489. PMID 8244010.
- ↑ "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development 121 (10): 3477–86. October 1995. doi:10.1242/dev.121.10.3477. PMID 7588080.
- ↑ "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters 144 (2–3): 151–5. November 1996. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.
Further reading
- "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1769 (9–10): 546–58. 2007. doi:10.1016/j.bbaexp.2007.06.004. PMID 17669516.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. January 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research 10 (5): 703–13. May 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
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